603-06-5

Basic information

• Product Name: 1,2-Dimethyl-3,4-dinitrobenzene
• Synonyms: 1,2-Dimethyl-3,4-dinitrobenzene;3,4-Dimethyl-1,2-dinitrobenzene
• CAS NO: 603-06-5
• Molecular Formula: C₈H₈N₂O₄
• Molecular Weight: 196.16
• Mol File: 603-06-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 1,2-Dimethyl-3,4-dinitrobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Dimethyl-3,4-dinitrobenzene(603-06-5)
• EPA Substance Registry System: 1,2-Dimethyl-3,4-dinitrobenzene(603-06-5)

Safety Data

• Hazardous Substances Data: 603-06-5(Hazardous Substances Data)

Usage

Appearance

Yellow crystalline solid

Uses

Intermediate in the synthesis of dyes
Intermediate in the synthesis of explosives
Intermediate in the synthesis of pharmaceuticals
Production of insecticides
Production of fungicides

Toxicity

Classified as a toxic and harmful substance

Health hazards

Can cause irritation to the skin, eyes, and respiratory system

Environmental impact

Potential environmental hazard due to persistence and bioaccumulation

Handling and disposal

Proper handling and disposal are essential to minimize impact on human health and the environment

Upstream product

• 95-47-6 o-xylene 
• 7697-37-2 nitric acid 
• 99-51-4 4-nitro-o-xylene 
• 108-24-7 acetic anhydride 
• 83-41-0 2,3-dimethylnitrobenzene 
• 99321-75-2 5,6-dimethyl-2,6-dinitrocyclohexa-2,4-dienyl acetate 
• 99321-70-7 5,6-dimethyl-2,6-dinitrocyclohexa-2,4-dienyl methyl ether 

Downstream Products

• 59146-96-2 2,3-dimethyl-6-nitroaniline 
• 75038-11-8 1,2-dimethyl-3,4,5-trinitro-benzene 
• 102312-36-7 2,3-dimethyl-1,4,5-trinitro-benzene 
• 89939-48-0 3-Nitro-4-amino-phthalsaeure 
• 89939-55-9 3-Nitro-4-hydroxylamino-phthalsaeure 
• 603-11-2 3-nitrophthalic acid 
• 5628-49-9 methyl 6-amino-2,3-dimethylbenzoate 
• 5628-59-1 5,6-dimethyl-2-hydroxybenzoic acid 
• 5628-60-4 methyl 6-hydroxy-2,3-dimethylbenzoate 
• 90564-16-2 acide dimethyl-2,3 nitro-6 benzoique 
• 90557-87-2 2,3-Dimethyl-6-nitro-benzamid 
• 90922-72-8 2,3-Dimethyl-6-nitro-benzoesaeure-methylester 
• 52911-60-1 2,3-dimethyl-6-nitrobenzonitrile 
• 92971-15-8 3,4-dinitrophthalic acid 

Relevant articles and documents

Nitration of deactivated aromatic compounds via mechanochemical reaction

A variety of deactivated arenes were nitrated to their corresponding nitro derivatives in excellent yields under high-speed ball milling condition using Fe(NO3)3·9H2O/P2O5 as nitrating reagent. A radical involved mechanism was proposed for this facial, eco-friendly, safe, and effective nitration reaction.

ipso Nitration. XXVI. Nitration of 1,2-dimethyl-4-nitrobenzene. Formation and reactions of adducts

Nitration of 1,2-dimethyl-4-nitrobenzene in a mixture of acetic anhydride and trifluoroacetic anhydride gives the diastereoisomers of 4,5-dimethyl-2,4-dinitrocyclohexa-2,5-dienyl acetate (50percent), in addition to the 1,2-dimethyldinitrobenzenes.In moderate and more strongly acid conditions the adduct gives 4-nitro-, 3,4-dinitro-, and 3,5-dinitro-o-xylene.In neutral and weakly acid solutions 4-nitro- and 3,5-dinitro-o-xylene are formed by a radical and a sigmatropic pathway.The adduct reacts facilely with nucleophiles by allylic substitution to give a 5,6-dimethyl-6-nitrocyclohexa-2,4-dienyl derivative which, in many instances, undergoes a second allylic substitution to a new 4,5-dimethyl-2,4-dinitrocyclohexa-2,5-dienyl derivative.Depending on the nature of the introduced substituent, these 2,4- and 2,5-dienyl products may eliminate nitrous acid, under the reaction conditions, to give the corresponding aromatic compound.The dienyl acetates undergo acid-catalysed transesterification to the corresponding dienols.