60320-32-3 Usage
Description
NSC 231656, also known as N-(5-Chloro-1,3,4-thiadiazol-2-yl)acetamide, is a chemical compound that serves as an impurity in the pharmaceutical drug Acetazolamide. It is identified as Acetazolamide impurity A and Acetazolamide EP Impurity A.
Usage:
Used in Pharmaceutical Industry:
NSC 231656 is used as an impurity in the manufacturing process of Acetazolamide (A161500) for the purpose of ensuring the quality and safety of the final drug product. It is crucial to monitor and control the levels of this impurity to maintain the efficacy and safety profile of Acetazolamide, which is used for various medical applications such as treating glaucoma, epilepsy, and altitude sickness.
Check Digit Verification of cas no
The CAS Registry Mumber 60320-32-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,3,2 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 60320-32:
(7*6)+(6*0)+(5*3)+(4*2)+(3*0)+(2*3)+(1*2)=73
73 % 10 = 3
So 60320-32-3 is a valid CAS Registry Number.
InChI:InChI=1/C4H4ClN3OS/c1-2(9)6-4-8-7-3(5)10-4/h1H3,(H,6,8,9)
60320-32-3Relevant articles and documents
GIAO/DFT 13C NMR Chemical Shifts of 1,3,4-thiadiazoles
Loghmani-Khouzani, Hossein,Rauckyte, Teresa,Osmialowski, Borys,Gawinecki, Ryszard,Kolehmainen, Erkki
, p. 2217 - 2225 (2008/02/10)
1H, 13C and 15N NMR spectra of 2-acetylamino-1,3,4-thiadiazole and its 5-substituted derivatives have been measured and assigned based on reference data, as well as homo- and heteronuclear 2 D NMR experiments. In addition, the GIAO/DFT approach at the B3LYP level of theory using the 6-311G basis set was used to calculate the 13C NMR chemical shifts. Although this method gives reliable results for 2-arylhydrazones of 1,3-diphenylpropanetrione, 2-phenacylpyridines, (Z)-2-(2-hydroxy-2-phenylvinyl)pyridines, 4-fluoroanilines, (1Z,3Z)-1,4-di(pyridin-2-yl)buta-1,3-dienediols and their tautomeric forms, the calculated chemical shifts for the 1,3,4-thiadiazoles studied are less satisfactory. Presence of the sulfur atom(s) seems to be responsible for such behavior.
