6038-19-3Relevant articles and documents
Preparation Method for Homocystein Thiolactone or Selenolactone
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Paragraph 0070-0074, (2021/09/14)
The present invention provides an expensive reagent such as homocysteine thiolactone or selenolactone as the main intermediate of erdosteine, or an expensive reagent such as HI. More specifically, A) a homoserine lactone or N - protected homoserine is reacted with a thiocarboxylic acid metal salt or selenocarboxylic acid metal salt (RCOXM, X=S or Se). B) Step A) of producing homocysteine thiolactone or homocysteine sonoactone by deprotection of N - protected homocysteine thiolactone or N - protected homocysteine seleactone. The present invention relates to a method for producing homocysteine thiactone or homocysteine senolactone or a salt thereof by the following reaction scheme. [Reaction Scheme] Then, this time. X Is S or Se, R and R ' are independently alkyl or aryl which is C1 - C6, and M is Na or K.
DL-homocysteine thiolactone hydrochloride and preparation method and applications thereof
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Paragraph 0021-0041; 0046, (2019/06/30)
The invention belongs to the technical field of medicine, and specifically relates to DL-homocysteine thiolactone hydrochloride and a preparation method and applications thereof. The synthesis methodof DL-homocysteine thiolactone hydrochloride comprises following steps: taking 2-methyl-4-chlorobutyryl chloride as the raw material to prepare an intermediate; distilling the intermediate, collectingdistillate; mixing the distillate with iodine and ammonia water to carry out reactions; and finally re-crystallizing and purifying the reaction product to obtain DL-homocysteine thiolactone hydrochloride. According to the synthesis method, 2-methyl-4-chlorobutyryl chloride is taken as the raw material to prepare DL-homocysteine thiolactone hydrochloride; and the preparation method has the advantages of low cost, small environmental pressure, safe and convenient production, and high yield, and is suitable for large scale production.
Process for the resolution of homocysteine-thiolactone
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Page/Page column 6, (2008/12/08)
The present invention relates to a process for the preparation of enantiomerically pure homocysteine-γ-thiolactone comprising optical resolution of racemic homocysteine-γ-thiolactone (I) with a chiral organic acid wherein one isomer is recovered as diastereomeric salt with the organic acid and the other isomer remaining in the mother liquor is submitted to racemisation with a catalytic amount of an aromatic aldehyde and submitted again to optical resolution with the same chiral organic acid.