60455-00-7

Basic information

• Product Name: 1-(pentyloxy)-1H-benzotriazole
• CAS NO: 60455-00-7
• Molecular Formula: C₁₁H₁₅N₃O
• Molecular Weight: 205.2563
• Mol File: 60455-00-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 308.5°C at 760 mmHg
• Flash Point: 140.3°C
• Density: 1.14g/cm³
• Vapor Pressure: 0.00068mmHg at 25°C
• Refractive Index: 1.58
• CAS DataBase Reference: 1-(pentyloxy)-1H-benzotriazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(pentyloxy)-1H-benzotriazole(60455-00-7)
• EPA Substance Registry System: 1-(pentyloxy)-1H-benzotriazole(60455-00-7)

Safety Data

• Hazardous Substances Data: 60455-00-7(Hazardous Substances Data)

Usage

General Description

1-(pentyloxy)-1H-benzotriazole, also known as PBTA, is a chemical compound that belongs to the class of benzotriazoles. It is commonly used as a UV absorber and light stabilizer in various applications, including plastics, coatings, and adhesives. PBTA provides excellent protection against UV radiation, which can degrade and discolor materials over time. Additionally, it is also used as a corrosion inhibitor for metals, particularly in industrial and marine environments. Its chemical structure includes a pentyloxy group that enhances its solubility and compatibility with various polymer systems, making it an effective and versatile additive for protecting materials against degradation and deterioration caused by UV exposure and corrosion.

Upstream product

• 110-53-2 1-Bromopentane 
• 2592-95-2 benzotriazol-1-ol 

Relevant articles and documents

Synthesis and evaluation of 1-hydroxybenzotriazole derivatives: Dual inhibitors of carbonic anhydrase ii and sodium hydrogen exchanger i

Ischemia reperfusion injury is responsible for impaired graft functioning in organ transplants, cerebral dysfunction, ischemic heart diseases, systemic inflammatory response syndrome, gastrointestinal dysfunction, and multiple organ dysfunction syndromes. Intracellular pH is critical for cell survival in ischemia reperfusion injury. Sodium hydrogen exchanger I and carbonic anhydrase II are critical in the regulation of intracellular pH. Inhibition of sodium hydrogen exchanger I and carbonic anhydrase II during reperfusion is found to ameliorate ischemia reperfusion injury separately. An attempt is made to synthesize dual inhibitors of sodium hydrogen exchanger and carbonic anhydrase to have better potential drug molecule in ischemia reperfusion injury treatment. The hydroxybenzotriazole is considered as a central pharmacophore for this dual activity and 12 derivatives are synthesized. All derivatives are tested for sodium hydrogen exchanger I and carbonic anhydrase II inhibitory activity. The tosylate derivative (12) is found to be the most potent derivative with IC50 158.7± 8.4 μM for carbonic anhydrase II and 31.07 ± 1.06 μM for sodium hydrogen exchanger I. Although the potency is less than standard drugs but this is the first report of dual inhibitor of carbonic anhydrase II and sodium hydrogen exchanger.