6048-14-2

Basic information

• Product Name: Phosphonium, [(3E)-2-oxo-4-phenyl-3-butenyl]triphenyl-, bromide
• CAS NO: 6048-14-2
• Molecular Formula: C28H24OP.Br
• Molecular Weight: 487.376
• Mol File: 6048-14-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: Phosphonium, [(3E)-2-oxo-4-phenyl-3-butenyl]triphenyl-, bromide(CAS DataBase Reference)
• NIST Chemistry Reference: Phosphonium, [(3E)-2-oxo-4-phenyl-3-butenyl]triphenyl-, bromide(6048-14-2)
• EPA Substance Registry System: Phosphonium, [(3E)-2-oxo-4-phenyl-3-butenyl]triphenyl-, bromide(6048-14-2)

Safety Data

• Hazardous Substances Data: 6048-14-2(Hazardous Substances Data)

Upstream product

• 122-57-6 1-Phenylbut-1-en-3-one 
• 22422-16-8 α-bromomethyl styryl cetone 
• 603-35-0 triphenylphosphine 
• 22422-16-8 (E)-1-bromo-4-phenylbut-3-en-2-one 

Downstream Products

• 98749-52-1 4-phenyl-1-(triphenylphosphoranylidene)-(3E)-buten-2-one 
• 923025-67-6 (5Z)-3,4-dimethyl-5-[(E)-2-oxo-4-phenylbut-3-enylidene]furan-2(5H)-one 
• 923025-74-5 2-(1-hydroxy-3-phenyl-allylidene)-4,5-dimethyl-cyclopent-4-ene-1,3-dione 
• 923025-68-7 (5E)-5-[(E)-2-oxo-4-phenylbut-3-enylidene]-3-phenylfuran-2(5H)-one 
• 923025-66-5 (5E)-3-methyl-5-[(E)-2-oxo-4-phenylbut-3-enylidene]furan-2(5H)-one 
• 60299-77-6 cinnamoyl cyanide 

Relevant articles and documents

Synthesis, antifungal activity, and structure-activity relationships of coruscanone A analogues

Coruscanone A, a plant-derived cyclopentenedione derivative, showed potent in vitro antifungal activity against Candida albicans and Cryptococcus neoformans comparable to amphotericin B and fluconazole. A series of analogues have been synthesized by modification of the cyclopentenedione ring, the enolic methoxy functionality, and the side chain styryl moiety of this natural product lead. A structurally close 1,4-benzoquinone analogue was also prepared. All the compounds were examined for their in vitro activity against major opportunistic fungal pathogens including C. albicans, C. neoformans, and Aspergillus fumigatus and fluconazole-resistant C. albicans strains, with several analogues demonstrating potent antifungal activity. Structure-activity relationship studies indicate that the 2-methoxymethylenecyclopent-4-ene-1,3-dione structural moiety is the pharmacophore responsible for the antifungal activity of this class of compounds while the side chain styryl-like moiety plays an important complementary role, presumably contributing to target binding.

Antifungal cyclopentenediones from Piper coruscans

Coruscanones A and B, two new antifungal cyclopentenedione derivatives, have been isolated from Piper coruscans and their structures elucidated by spectroscopic and chemical methods. Coruscanone A exhibits significant antifungal activity against Candida a