60536-21-2

Basic information

• Product Name: 10-benzylacridin-9(10H)-one
• Synonyms: 10-(Phenylmethyl)-9(10H)-acridinone; 9(10H)-acridinone, 10-(phenylmethyl)-
• CAS NO: 60536-21-2
• Molecular Formula: C₂₀H₁₅NO
• Molecular Weight: 285.3392
• Mol File: 60536-21-2.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 472°C at 760 mmHg
• Flash Point: 191.7°C
• Density: 1.23g/cm³
• Vapor Pressure: 4.43E-09mmHg at 25°C
• Refractive Index: 1.67
• CAS DataBase Reference: 10-benzylacridin-9(10H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 10-benzylacridin-9(10H)-one(60536-21-2)
• EPA Substance Registry System: 10-benzylacridin-9(10H)-one(60536-21-2)

Safety Data

• Hazardous Substances Data: 60536-21-2(Hazardous Substances Data)

Usage

Molecular weight

313.36 g/mol

Structure

A derivative of acridin-9(10H)-one with a benzyl group attached to the 10th position

Biological activity

Potential pharmacological properties

Applications

Studied for its potential as an antitumor and antimicrobial agent

Research focus

Investigated for possible use in the development of new drugs for the treatment of various diseases and conditions

Field of interest

Medicinal chemistry

Chemical properties

Its chemical structure and properties make it a promising candidate for further research and development

Solubility

Not mentioned in the material provided

Stability

Not mentioned in the material provided

Upstream product

• 78943-58-5 N-benzyl-5H-dibenzoazepine 
• 91-40-7 2-(phenylamino)benzoic acid 
• 62-53-3 aniline 
• 118-91-2 ortho-chlorobenzoic acid 
• 1621107-08-1 C₂₇H₂₃NO₂ 
• 1621107-14-9 C₂₀H₁₉NO 
• 88-67-5 2-Iodobenzoic acid 
• 201230-82-2 carbon monoxide 
• 76464-99-8 N-benzyl-2-iodoaniline 
• 88284-48-4 2-(trimethylsilyl)phenyl trifluoromethanesulfonate 
• 25187-01-3 2,2’-dibromobenzophenone 
• 100-46-9 benzylamine 
• 244205-40-1 (2-bromophenyl)boronic acid 
• 100-44-7 benzyl chloride 

Downstream Products

• 947700-72-3 C₂₇H₂₃NO 
• 947700-74-5 C₂₇H₂₃NO₂ 
• 947700-75-6 C₂₇H₂₁NO₃ 
• 947700-76-7 C₃₀H₂₃NO 
• 947700-77-8 C₂₆H₂₀ClNO 
• 947700-78-9 C₂₇H₂₀F₃NO 
• 947700-70-1 C₂₇H₂₃NO 
• 947700-71-2 C₂₇H₂₃NO 
• 36519-50-3 C₆H₄C(OH)(C₆H₅)N(CH₂C₆H₅)C₆H₄ 
• 87742-33-4 10-benzyl-9,10-dihydroacridine 
• 78943-58-5 N-benzyl-5H-dibenzoazepine 
• 1372853-59-2 10-benzyl-9-(nitromethyl)-9,10-dihydroacridine 
• 1372853-56-9 2-(10-benzyl-9,10-dihydroacridin-9-yl)malononitrile 
• 1372853-53-6 dimethyl 2-(10-benzyl-9,10-dihydroacridin-9-yl)malonate 

Relevant articles and documents

A one-pot construction of acridones by rhodium catalyzed reaction of N-phenyl-2-(1-sulfonyl-1H-1,2,3-triazol-4-yl)aniline

A one-pot synthesis of N-alkyl acridone via rhodium catalyzed decomposition of N-phenyl-2-(1-sulfonyl-1H-1,2,3-triazol-4-yl)aniline and subsequent oxidative C–C bond fragmentation has been developed. 14 examples are presented and the yields range from 30% to 80%.

Synthesis of Acridones by Palladium-Catalyzed Buchwald-Hartwig Amination

The Buchwald-Hartwig amination allows an efficient and convenient synthesis of biologically and pharmaceutically important acridones by formation of a six-membered ring. With the described method, a number of derivatives have been synthesized in up to 95% yield by using a variety of anilines as well as benzylic and aliphatic amines.

Photocatalytic oxidation synthesis method of acridone compound

The invention discloses a photocatalytic oxidation synthesis method of an acridone compound. According to the method, a 9,10-dihydroacridine compound is used as a reaction substrate, 2,3-dichloro-5,6-dinitrile group-1,4-benzoquinone (DDQ) and tert-butyl nitrite (TBN) are used as catalysts, acetic acid is used as a reaction aid, oxygen is used as an oxidant, the reaction substrate reacts in a 1,2-dichloroethane solvent at normal temperature and pressure under blue light irradiation, and after the completion of the reaction, the acridone compound is obtained by separation treatment. According tothe synthesis method provided by the invention, a traditional heating reaction is replaced with an illumination reaction, thereby saving energy; no transition metal catalyst is used; and the productyield is high under optimized conditions.