60553-32-4 Usage
Structure
A derivative of pyridine with a tetrahydropyridine ring, a methyl group, and a 1,3-dioxolane ring
Organic synthesis
Used as a building block for more complex molecules
Pharmaceutical research
Potential use in the development of new drugs or as a research tool for studying the biological activity of pyridine derivatives
Agrochemicals
May have uses in the field of agrochemicals
Precursor
Used as a precursor in the production of other chemicals
Tetrahydropyridine ring
A six-membered nitrogen-containing ring with four carbon atoms and two nitrogen atoms, all in a saturated state
Methyl group
A single carbon atom bonded to three hydrogen atoms (-CH3)
1,3-Dioxolane ring
A four-membered ring containing two oxygen atoms and two carbon atoms
Reactivity
May undergo various chemical reactions due to the presence of the tetrahydropyridine and 1,3-dioxolane rings
Solubility
Likely soluble in organic solvents such as ethanol, methanol, or acetone
Boiling point
Not provided, but expected to be relatively high due to the molecular size and complexity
Melting point
Not provided, but expected to be relatively low due to the presence of the 1,3-dioxolane ring
Density
Not provided, but expected to be influenced by the molecular structure and size
Appearance
Not provided, but likely a colorless to light-colored solid or liquid depending on the temperature and purity
Toxicity
Not provided, but should be handled with care due to its potential biological activity
Hazards
Not provided, but may pose risks such as flammability, irritancy, or reactivity with other chemicals
Storage
Should be stored in a cool, dry, and well-ventilated area, away from incompatible substances and sources of ignition
Synthesis
Not provided, but likely synthesized through various chemical reactions involving the formation of the tetrahydropyridine and 1,3-dioxolane rings, as well as the introduction of the methyl group.
Check Digit Verification of cas no
The CAS Registry Mumber 60553-32-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,0,5,5 and 3 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 60553-32:
(7*6)+(6*0)+(5*5)+(4*5)+(3*3)+(2*3)+(1*2)=104
104 % 10 = 4
So 60553-32-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H17NO2/c1-10(12-7-8-13-10)9-3-5-11(2)6-4-9/h3H,4-8H2,1-2H3
60553-32-4Relevant articles and documents
Synthesis and in vivo and in vitro evaluation of isoarecolone and derivatives
Beach, J. Warren,Damaj, M. Imad,Jonnala, Ramamohana R.,Terry Jr., Alvin V.,Buccafusco, Jerry J.
, p. 510 - 522 (2007/10/03)
The synthesis of the N-ethyl and N-phenylethyl derivatives of isoarecolone are described. These compounds were evaluated in vitro for their ability to displace [3H](±)epibatidine and/or [3H](-) nicotine from nicotinic receptors derived from rat cerebral cortex and their ability to inhibit acetylcholinesterase. The N-ethyl derivative and isoarecolone were evaluated in vivo for their antinociceptive, hypothermia and hypomotility activity in mice. The in vivo activity of isoareeolone was found to the reversible by mecamylamine, however the N-ethyl derivative was found to be insensitive to blockade by mecamylamine.
Synthesis and cytotoxic activity of hydroxylated derivatives of olivacine in relation with their biotransformation
Maftouh,Besselievre,Monsarrat,Lesca,Meunier,Husson,Paoletti
, p. 708 - 714 (2007/10/02)
The chemical synthesis of 9-hydroxyolivacine and 7-hydroxyolivacine based on a biomimetic approach is described. These two hydroxylated derivatives have been found as main in vitro metabolites of olivacine after incubation with rat hepatic microsomes. The pretreatment of animals with benzo[a]pyrene caused a large increase in both microsomal hydroxylations, whereas the pretreatment with phenobarbital caused a weak increase, with a preservation of 9-hydroxylation/7-hydroxylation ratio >1 in both cases. The two hydroxyolivacines have been also found as principal in vivo metabolites of olivacine in rat bile as glucuronide and sulfate conjugates. The pretreatment of animals with benzo[a]pyrene reverses the 9-hydroxyolivacine/7-hydroxyolivacine ratio excretion in bile to a value that is 1H NMR spectra. Hydroxylation at position 9 increases the in vitro cytotoxicity against leukemia L1210 cells (ID50 = 0.06 μM compared to 2.03 μM for olivacine) and an opposite effect is observed for hydroxylation at position 7 (ID50 = 12.8 μM). On the other hand, hydroxylation at position 9 has no effect on the in vivo antitumor activity against L1210. This might be related to the oxidative and conjugative metabolic pathways that play an important role in antitumor activity and deactivation of olivacine and its hydroxy metabolites.
