60729-37-5

Basic information

• Product Name: 4-broMo-5-chlorothiophene-2-carboxylic acid
• Synonyms: 4-broMo-5-chlorothiophene-2-carboxylic acid;2-Chloro-3-bromo-5-thiophenecarobylic acid;4-bromo-5-chloro-2-Thiophenecarboxylic acid
• CAS NO: 60729-37-5
• Molecular Formula: C₅H₂BrClO₂S
• Molecular Weight: 241.49018
• Mol File: 60729-37-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: >200 °C
• Boiling Point: 342.3±42.0 °C(Predicted)
• Appearance: /
• Density: 2.019±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.31±0.10(Predicted)
• CAS DataBase Reference: 4-broMo-5-chlorothiophene-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-broMo-5-chlorothiophene-2-carboxylic acid(60729-37-5)
• EPA Substance Registry System: 4-broMo-5-chlorothiophene-2-carboxylic acid(60729-37-5)

Safety Data

• Hazardous Substances Data: 60729-37-5(Hazardous Substances Data)

Usage

General Description

4-Bromo-5-chlorothiophene-2-carboxylic acid is a chemical compound with the molecular formula C6H3BrClO2S. It is a heterocyclic compound containing a thiophene ring with a carboxylic acid group attached. The presence of bromine and chlorine atoms on the thiophene ring imparts unique chemical and physical properties to the compound. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and materials. The compound may also have potential applications in organic electronics and optoelectronics due to its electronic properties.

Upstream product

• 123418-67-7 1-(4-bromo-5-chlorothiophen-2-yl)ethan-1-one 
• 24065-33-6 5-Chlorothiophene-2-carboxylic acid 
• 16694-18-1 4-bromo-thiophene-2-carboxylic acid 
• 6310-09-4 2-acetyl-5-chlorothiophene 

Downstream Products

• 1047645-46-4 1,1-dimethylethyl (2-{[(4-bromo-5-chloro-2-thienyl)carbonyl]amino}-3-phenylpropyl)carbamate 
• 1047645-01-1 4-bromo-5-chloro-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-2-thiophenecarboxamide 
• 1047645-09-9 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride 
• 1047645-08-8 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride 
• 1047645-04-4 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide hydrochloride 
• 1047645-51-1 5-chloro-4-(1,4-dimethyl-1H-pyrazol-5-yl)-N-((1S)-2-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-2-thiophenecarboxamide 
• 1047645-07-7 1,1-dimethylethyl {(2S)-2-({[5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-3-[2-(trifluoromethyl)phenyl]propyl}carbamate 
• 1047645-10-2 1,1-dimethylethyl {(2S)-2-({[4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-5-chloro-2-thienyl]carbonyl}amino)-3-[2-(trifluoromethyl)phenyl]propyl}carbamate 
• 1047645-03-3 1,1-dimethylethyl {(2S)-2-({[5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-3-[2-(trifluoromethyl)phenyl]propyl}carbamate 
• 1047643-88-8 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-bromo-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide 
• 1047643-87-7 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide 
• 1047644-57-4 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(1,4-dimethyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide 
• 1047645-47-5 1,1-dimethylethyl [2-({[5-chloro-4-(1-ethyl-1H-pyrazol-5-yl)-2-thienyl]carbonyl}amino)-3-phenylpropyl]carbamate 
• 1047643-81-1 N-((1S)-2-amino-1-{[2-(trifluoromethyl)phenyl]methyl}ethyl)-5-chloro-4-(1-methyl-1H-pyrazol-5-yl)-2-thiophenecarboxamide 

Relevant articles and documents

INHIBITORS OF AKT ACTIVITY

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Herbicidal Thienylureas, I

Syntheses of the title substances as potential herbicides are described by a modified Curtius degradation of corresponding thiophene carboxylic acids, obtained in turn by haloform reaction of appropriate acetyl thiophenes.Regioselective substitution reactions of thiophenes were key steps for the construction of desired substitution patterns.Structure-activity considerations show that especially the 3-thienyl ureas 36 and 38 exhibit significant herbicidal activity comparable with commercial products. - Keywords: Curtius degradation; Herbicides; Thiophenes; Ureas; Urethanes