60803-26-1

Basic information

• Product Name: 2-(tert-butyl)-4,6-diiodophenol
• Synonyms: 2-(tert-butyl)-4,6-diiodophenol;2-(1,1-dimethylethyl)-4,6-diiodophenol;Phenol, 2-(1,1-dimethylethyl)-4,6-diiodo-
• CAS NO: 60803-26-1
• Molecular Formula: C₁₀H₁₂I₂O
• Molecular Weight: 402.01062
• Mol File: 60803-26-1.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2-(tert-butyl)-4,6-diiodophenol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tert-butyl)-4,6-diiodophenol(60803-26-1)
• EPA Substance Registry System: 2-(tert-butyl)-4,6-diiodophenol(60803-26-1)

Safety Data

• Hazardous Substances Data: 60803-26-1(Hazardous Substances Data)

Usage

General Description

2-(tert-butyl)-4,6-diiodophenol is a chemical compound with the molecular formula C10H13I2O. It is a derivative of phenol with two iodine atoms attached to the 4 and 6 positions of the aromatic ring, and a tert-butyl group attached to the 2 position. 2-(tert-butyl)-4,6-diiodophenol is often used as a reagent in organic synthesis and as a building block in the preparation of various organic compounds. It is a white to off-white crystalline solid that is sparingly soluble in water but soluble in organic solvents. 2-(tert-butyl)-4,6-diiodophenol has potential applications in the pharmaceutical, agrochemical, and materials science industries. It is important to handle and use this compound with proper safety precautions due to its potential hazards.

Upstream product

• 39068-23-0 sodium 2-tert-butylphenolate 
• 88-18-6 2-tert-Butylphenol 

Downstream Products

• 1132940-53-4 1-(3-tert-butyl-5-iodo-4-methoxyphenyl)-2,4-dihydropyrimidine-2,4(1H,3H)-dione 
• 1132935-63-7 N-(6-(3-(tert-butyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl)methanesulfonamide 
• 1355646-97-7 6-(3-tert-butyl-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-2-methoxyphenyl)naphthalen-2-yl 1,1,2,2,3,3,4,4,4-nonafluorobutane-1-sulfonate 
• 1355646-93-3 1-(3-tert-butyl-5-(6-hydroxynaphthalen-2-yl)-4-methoxyphenyl)-pyrimidine-2,4(1H,3H)-dione 
• 60803-25-0 2-(tert-butyl)-4-iodophenol 
• 1132940-51-2 1-tert-butyl-3,5-diiodo-2-methoxybenzene 
• 364068-82-6 carbonic acid tert-butyl ester 2-tert-butyl-6-iodo-4-[(triisopropylsilanyl)-ethynyl]-phenyl ester 
• 364068-81-5 acetic acid 2-tert-butyl-6-iodo-4-[(triisopropylsilanyl)-ethynyl]-phenyl ester 
• 364068-80-4 acetic acid 2-tert-butyl-4,6-diiodo-phenyl ester 

Relevant articles and documents

Discovery and Development of Metal-Catalyzed Coupling Reactions in the Synthesis of Dasabuvir, an HCV-Polymerase Inhibitor

Dasabuvir (1) is an HCV polymerase inhibitor which has been developed as a part of a three-component direct-acting antiviral combination therapy. During the course of the development of the synthetic route, two novel coupling reactions were developed. First, the copper-catalyzed coupling of uracil with aryl iodides, employing picolinamide 16 as the ligand, was discovered. Later, the palladium-catalyzed sulfonamidation of aryl nonaflate 33 was developed, promoted by electron-rich palladium complexes, including the novel phosphine ligand, VincePhos (50). This made possible a convergent, highly efficient synthesis of dasabuvir that significantly reduced the mutagenic impurity burden of the process.

PROCESS FOR PREPARING ANTIVIRAL COMPOUNDS

This disclosure is directed to: (a) processes for preparing a compound and salts thereof that, inter alia, are useful for inhibiting hepatitis C virus (HCV); (b) intermediates useful for the preparation of the compound and salts; (c) pharmaceutical compositions comprising the compound or salts; and (d) methods of use of such compositions.

N-PHENYL-DIOXO-HYDROPYRIMIDINES USEFUL AS HEPATITIS C VIRUS (HCV) INHIBITORS

This invention relates to: (a) compounds and salts thereof that, inter alia, inhibit HCV; (b) intermediates useful for the preparation of such compounds and salts; (c) compositions comprising such compounds and salts; (d) methods for preparing such interm