608519-36-4Relevant articles and documents
Palladium-catalyzed oxalyl amide assisted direct ortho-alkynylation of arylalkylamine derivatives at δ and ε positions
Guan, Mingyu,Chen, Changpeng,Zhang, Jingyu,Zeng, Runsheng,Zhao, Yingsheng
supporting information, p. 12103 - 12106 (2015/07/28)
Palladium-catalyzed oxalyl amide directed ortho-alkynylation of arylalkylamine derivatives is reported for the first time. A wide variety of β-arylethamine and γ-arylpropamine derivatives are compatible with this protocol. This method provides a general means to synthesize substituted alkynylarylalkylamine derivatives, highlighting the ability of oxalyl amide in promoting C-H functionalization at unique δ and ε positions.