60960-88-5Relevant articles and documents
Photoenzymatic Generation of Unstabilized Alkyl Radicals: An Asymmetric Reductive Cyclization
Clayman, Phillip D.,Hyster, Todd K.
supporting information, p. 15673 - 15677 (2020/10/18)
Flavin-dependent "ene"-reductases can generate stabilized alkyl radicals when irradiated with visible light; however, they are not known to form unstabilized radicals. Here, we report an enantioselective radical cyclization using alkyl iodides as precursors to unstabilized nucleophilic radicals. Evidence suggests this species is accessed by photoexcitation of a charge-transfer complex that forms between flavin and substrate within the protein active site. Stereoselective delivery of a hydrogen atom from the flavin semiquinone to the prochiral radical formed after cyclization provides high levels of enantioselectivity across a variety of substrates. Overall, this transformation demonstrates that photoenzymatic catalysis can address long-standing selectivity challenges in the radical literature.
Diastereoselective [2,3]-Sigmatropic Rearrangement of N-Allyl Ammonium Ylides
Erkman, Kristin,J?rving, Ivar,Kaabel, Sandra,Kanger, T?nis,Murre, Aleksandra
, p. 4183 - 4197 (2019/11/14)
A rapid and diastereoselective method was developed for the [2,3]-sigmatropic rearrangement of N-Allyl ammonium ylides, affording products in up to 95percent isolated yields and up to 97:3 dr; most of the desired products were formed within 1 minute. For
Method for preparing naftifine hydrochloride
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, (2018/07/06)
The invention provides a method for preparing naftifine hydrochloride. The finished naftifine hydrochloride is obtained through subjecting relatively-cheap cinnamyl alcohol, which serves as a raw material, to chlorinating-reagent chlorinating, methyl-amination and 1-chloromethyl naphthalene substitution sequentially, and finally, carrying out acidification salt-forming and crystallization refining. According to the method provided by the invention, all intermediates in first three steps of reactions are subjected to a reaction without purification, process flows are continuous and non-intermittent, the operation is simplified, the yield and production efficiency of the product are increased, and meanwhile, the purity of the product is ensured, so that the method is applicable to industrialization; and meanwhile, the method has the advantages of simple reaction conditions, low cost and environment-friendliness.