609789-17-5 Usage
Description
3-AMINO-AZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is an organic compound that serves as a key intermediate in the synthesis of various pharmaceutical compounds. It is characterized by its unique chemical structure, which includes an azepane ring with an amino group and a carboxylic acid tert-butyl ester functional group. This structure endows it with specific reactivity and properties that make it valuable in the development of therapeutic agents.
Uses
Used in Pharmaceutical Industry:
3-AMINO-AZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a key intermediate in the synthesis of ureidothiophenes, which are a class of compounds with potential applications in the treatment of neoplasms (abnormal growths of cells). 3-AMINO-AZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER's unique structure allows for the development of CHK1 kinase inhibitors, which play a crucial role in regulating cell division and are often overactive in cancer cells. By inhibiting CHK1 kinase, these compounds can help to prevent the uncontrolled cell division associated with cancer and potentially contribute to the development of novel cancer treatments.
Additionally, 3-AMINO-AZEPANE-1-CARBOXYLIC ACID TERT-BUTYL ESTER may also be used in other applications within the pharmaceutical industry, such as the development of other targeted therapies or as a building block for the synthesis of various drug candidates. Its versatility and unique chemical properties make it a valuable tool in the ongoing search for new and effective treatments for a wide range of diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 609789-17-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 6,0,9,7,8 and 9 respectively; the second part has 2 digits, 1 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 609789-17:
(8*6)+(7*0)+(6*9)+(5*7)+(4*8)+(3*9)+(2*1)+(1*7)=205
205 % 10 = 5
So 609789-17-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H22N2O2/c1-11(2,3)15-10(14)13-7-5-4-6-9(12)8-13/h9H,4-8,12H2,1-3H3
609789-17-5Relevant articles and documents
β-Functionalization of Saturated Aza-Heterocycles Enabled by Organic Photoredox Catalysis
Holmberg-Douglas, Natalie,Choi, Younggi,Aquila, Brian,Huynh, Hoan,Nicewicz, David A.
, p. 3153 - 3158 (2021/04/06)
The direct β-functionalization of saturated aza-heterocycles has remained a synthetic challenge because of the remote and unactivated nature of β-C-H bonds in these motifs. Herein, we demonstrate the β-functionalization of saturated aza-heterocycles enabl
Palladium-mediated N-arylation of heterocyclic diamines: Insights into the origin of an unusual chemoselectivity
Cabello-Sanchez, Noemi,Jean, Ludovic,Maddaluno, Jacques,Lasne, Marie-Claire,Rouden, Jacques
, p. 2030 - 2039 (2007/10/03)
The chemoselectivity of the palladium-mediated reaction of bromobenzene with various heterocyclic diamines was studied. Whatever the ligand used, 3-aminopyrrolidine underwent arylation of the secondary amine function (> 82%), whereas the more flexible 3-aminoazepinine was arylated on its primary function (>70%). The ratio "arylation of primary amine versus arylation of secondary amine" of 3-aminopiperidine with bromobenzene varied from 90:10 (BINAP, electron-enriched and hindered biphenyls L2 or L3) to 32:68 with the Josiphos-type ligand L10. The same trend was observed when 4-aminopiperidine was used (82:18 with L2 and 17:83 with L10). This selectivity can be tuned by the choice of aryl halide partners having different steric and electronic properties. A cooperative effect of both nitrogens of diamines during the reaction was deduced from competitive experiments. Finally, 13C and 31P NMR experiments, carried out with 3-aminopyrrolidine at room temperature, support a fast coordination of the primary amine to the metal. Indeed, a palladium complex resulting from the unusual displacement of one phosphane group of the intermediate ArPdX(BINAP) by the primary amino group was characterized.
