610314-16-4

Basic information

• Product Name: (S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(4-methoxy-benzylamino)-propionic acid methyl ester
• Synonyms: (S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(4-methoxy-benzylamino)-propionic acid methyl ester
• CAS NO: 610314-16-4
• Molecular Weight: 474.384
• Mol File: 610314-16-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: (S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(4-methoxy-benzylamino)-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(4-methoxy-benzylamino)-propionic acid methyl ester(610314-16-4)
• EPA Substance Registry System: (S)-3-[4-(2,6-Dichloro-benzyloxy)-phenyl]-2-(4-methoxy-benzylamino)-propionic acid methyl ester(610314-16-4)

Safety Data

• Hazardous Substances Data: 610314-16-4(Hazardous Substances Data)

Upstream product

• 123-11-5 4-methoxy-benzaldehyde 

Downstream Products

• 1342305-95-6 N-[(S)-2-chloropropionyl]-N-p-methoxybenzyl-L-Tyr(2,6-dichlorobenzyl)-OMe 
• 1342305-97-8 (3S,4S)-4-p-(2,6-dichlorobenzyloxy)benzyl-1-p-methoxybenzyl-4-methoxycarbonyl-3-methyl-2-azetidinone 
• 1342305-99-0 (3S,4S)-4-carboxy-4-p-(2,6-dichlorobenzyloxy)benzyl-1-p-methoxybenzyl-3-methyl-2-azetidinone 
• 1342306-05-1 (3S,4S)-4-p-(2,6-dichlorobenzyloxy)benzyl-1-p-methoxybenzyl-3-methyl-4-[2-(piperidin-1-yl)ethyl]carbamoyl-2-azetidinone 
• 610314-22-2 (S)-2-[(2-Chloro-acetyl)-(4-methoxy-benzyl)-amino]-3-[4-(2,6-dichloro-benzyloxy)-phenyl]-propionic acid methyl ester 

Relevant articles and documents

Optically active 1,3,4,4-tetrasubstituted β-lactams: Synthesis and evaluation as tumor cell growth inhibitors

The in vitro cytotoxicity assays of several enantiopure (3S,4S)- and (3R,4R)-1,3,4,4-tetrasubstituted β-lactams derived from amino acids have shown that the (3S,4S)-4-benzyl-1-p-methoxybenzyl-3-methyl-4-methoxycarbonyl derivative 2a, obtained from Phe, displays significant activity, which is comparable to that of the anticancer drug Doxorubicin against HT29 cell lines. Modifications at positions 1 and 4 of the β-lactam ring led to identify the Tyr(2,6-ClBz) analogu 26d with similar activity data to those of 2a. The synthesis and SAR of all these tetrasubstituted β-lactams are reported here.