6109-15-5

Basic information

• Product Name: 10-butylphenothiazine 5,5-dioxide
• Synonyms: 10-butyl-10H-phenothiazine 5,5-dioxide; 10H-phenothiazine, 10-butyl-, 5,5-dioxide
• CAS NO: 6109-15-5
• Molecular Formula: C₁₆H₁₇NO₂S
• Molecular Weight: 287.3767
• Mol File: 6109-15-5.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 462.5°C at 760 mmHg
• Flash Point: 233.5°C
• Density: 1.226g/cm³
• Vapor Pressure: 9.79E-09mmHg at 25°C
• Refractive Index: 1.604
• CAS DataBase Reference: 10-butylphenothiazine 5,5-dioxide(CAS DataBase Reference)
• NIST Chemistry Reference: 10-butylphenothiazine 5,5-dioxide(6109-15-5)
• EPA Substance Registry System: 10-butylphenothiazine 5,5-dioxide(6109-15-5)

Safety Data

• Hazardous Substances Data: 6109-15-5(Hazardous Substances Data)

Usage

Chemical class

Phenothiazine

Composition

Butyl group attached to the phenothiazine core, dioxide group at the 5,5-positions

Applications

Pharmacology and medicine

Antipsychotic effects

Blocks dopamine receptors in the brain

Antiemetic properties

Useful in treating nausea and vomiting

Potential

Inhibiting the growth of cancer cells

Versatility

Various pharmaceutical and medical applications

Upstream product

• 92-84-2 10H-phenothiazine 
• 5909-56-8 N-butylphenothiazine 
• 109-65-9 1-bromo-butane 
• 1209-66-1 phenothiazine 5,5-dioxide 

Relevant articles and documents

Sodium sulfate-hydrogen peroxide-sodium chloride adduct: selective protocol for the oxidative bromination, iodination and temperature dependent oxidation of sulfides to sulfoxides and sulfones

The regioselective bromination and iodination of unprotected aromatic primary amines using enclathrated hydrogen peroxide as an oxidant under mild conditions has been developed, in which potassium bromide (KBr) and potassium iodide (KI) were used as brominating and iodinating agents, respectively. The adduct shows not only regioselectivity for para- or ortho-isomers but also a remarkable chemoselectivity for monobromination. Selective oxidation of sulfides to sulfoxides and sulfones has also been studied and good to excellent yields of the desired products were obtained. Acetic acid was found to be the solvent of choice for these reactions. This simple method represents an ecologically benign and alternative pathway for the oxidative halogenation of anilines and the oxidation of sulfides to sulfoxides and sulfones.

Selective oxidaton methods for preparation of N-alkylphenothiazine sulfoxides and sulfones

Efficient and selective oxidation methods for preparation of N-alkylphenothiazine sulfoxides 2a-h and sulfones 3a-h starting from N-alkylphenothiazines 1a-h are described.