6125-63-9

Basic information

• Product Name: (E)-3-(2-furyl)acrylonitrile
• Synonyms: (E)-3-(2-furyl)acrylonitrile;(E)-3-(2-Furanyl)acrylonitrile;(E)-3-(2-Furanyl)propenenitrile;(E)-3-(2-Furyl)-2-propenenitrile;(αE)-2-Furanacrylonitrile;(αE)-Furan-2-acrylonitrile;(E)-3-(furan-2-yl)prop-2-enenitrile
• CAS NO: 6125-63-9
• Molecular Formula: C₇H₅NO
• Molecular Weight: 119.1207
• Product Categories: Heterocyclic Compounds
• Mol File: 6125-63-9.mol
• Article Data: 26

Chemical Properties

• Melting Point: 34 °C
• Boiling Point: 216.8 °C at 760 mmHg
• Flash Point: 87.2 °C
• Appearance: /
• Density: 1.117 g/cm³
• CAS DataBase Reference: (E)-3-(2-furyl)acrylonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(2-furyl)acrylonitrile(6125-63-9)
• EPA Substance Registry System: (E)-3-(2-furyl)acrylonitrile(6125-63-9)

Safety Data

• Hazardous Substances Data: 6125-63-9(Hazardous Substances Data)

Usage

General Description

(E)-3-(2-furyl)acrylonitrile is a chemical compound with the molecular formula C7H5NO. It is a yellow liquid with a strong, sweet, and nutty odor. (E)-3-(2-furyl)acrylonitrile is used in the production of perfumes, pharmaceuticals, and other organic chemicals. It is also used as a precursor in organic synthesis reactions, particularly in the formation of heterocyclic compounds. (E)-3-(2-furyl)acrylonitrile is considered to be a hazardous chemical, and exposure to high concentrations can cause irritation to the skin, eyes, and respiratory system. It is important to handle and store this compound with care and in accordance with safety regulations.

Upstream product

• 122-52-1 triethyl phosphite 
• 98-01-1 furfural 
• 793706-87-3 (1,1-dimethylethoxy)diphenylsilylacetonitrile 
• 98-00-0 (2-furyl)methyl alcohol 
• 16640-68-9 cyanomethylene triphenylphosphorane 
• 39511-08-5 (E)-3-(2-furanyl)-2-propenal 
• 75-05-8 acetonitrile 
• 773837-37-9 sodium cyanide 
• 100074-10-0 2,2-dibromovinyl-2-furan 
• 527-69-5 2-furancarbonyl chloride 
• 107-13-1 acrylonitrile 
• 590-17-0 cyanomethyl bromide 
• 2181-42-2 trimethylsulphonium iodide 
• 107-14-2 chloroacetonitrile 

Downstream Products

• 21446-61-7 3-(furan-2-yl)propanenitrile 
• 18873-35-3 (Z)-β-(5-Nitro-fur-2-yl)-acrylonitril 
• 18873-36-4 (E)-β-(5-Nitro-fur-2-yl)-acrylonitril 
• 135547-97-6 3-(3-Benzoyl-2-methyl-isothioureido)-4-furan-2-ylmethyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 135547-96-5 3-(3-Benzoyl-thioureido)-4-furan-2-ylmethyl-1H-pyrrole-2-carboxylic acid methyl ester 
• 539-47-9 3-(fur-2-yl)crotonic acid 
• 604800-01-3 1-[2-(2-furanyl)vinyl]cyclopropylamine 

Relevant articles and documents

Preparation method of nitrile compound

The present invention belongs to the field of organic synthesis technology, specifically relates to a method for preparing a nitrile compound, aldehyde oxime derivatives as raw materials, adding DPPA and DBU, reacting in an organic solvent, one step to pr

Development and Utilization of a Palladium-Catalyzed Dehydration of Primary Amides to Form Nitriles

A palladium(II) catalyst, in the presence of Selectfluor, enables the efficient and chemoselective transformation of primary amides into nitriles. The amides can be attached to aromatic rings, heteroaromatic rings, or aliphatic side chains, and the reactions tolerate steric bulk and electronic modification. Dehydration of a peptaibol containing three glutamine groups afforded structure-activity relationships for each glutamine residue. Thus, this dehydration can act similarly to an alanine scan for glutamines via synthetic mutation.

One-Pot Synthesis of α,β-Unsaturated Esters, Ketones, and Nitriles from Alcohols and Phosphonium Salts

A general method for the synthesis of α,β-unsaturated esters, ketones, and nitriles is successfully achieved by a one-pot copper-catalyzed oxidation with O 2 in air as oxidant. The solvent mixture of acetonitrile and formamide (1:1) is optimized to ensure the oxidation of alcohols, deprotonation of phosphonium salt, and Wittig reaction occur efficiently in one pot. A broad range of substrates has been explored for this process, including three electron-withdrawing group (CO 2 Et, COPh, CN) functionalized phosphonium salts. They reacted not only with benzylic and heteroaromatic alcohols, but also with aliphatic alcohols, forming the corresponding α,β-unsaturated esters, ketones, and nitriles in moderate to excellent yields.