612850-65-4

Basic information

• Product Name: 2-chloro-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide
• Synonyms: 2-chloro-N-(1-oxo-3H-2-benzofuran-5-yl)acetamide;2-chloro-N-(1-oxo-3H-2-benzofuran-5-yl)ethanamide;2-chloro-N-(1-oxo-3H-isobenzofuran-5-yl)acetamide;2-chloro-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide;acetamide, 2-chloro-N-(1,3-dihydro-1-oxo-5-isobenzofuranyl;2-chloro-N-(1-keto-3H-isobenzofuran-5-yl)acetamide;2-Chloro-N-(1-oxo-1,3-dihydro-isobenzofuran-5-yl)-acetamide
• CAS NO: 612850-65-4
• Molecular Formula: C₁₀H₈ClNO₃
• Molecular Weight: 225.62842
• Mol File: 612850-65-4.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-chloro-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide(612850-65-4)
• EPA Substance Registry System: 2-chloro-N-(1-oxo-1,3-dihydro-2-benzofuran-5-yl)acetamide(612850-65-4)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 612850-65-4(Hazardous Substances Data)

Upstream product

• 65399-05-5 5-amino-3H-isobenzofuran-1-one 
• 541-88-8 Chloroacetic anhydride 
• 79-04-9 chloroacetyl chloride 

Relevant articles and documents

Design, synthesis and biological evaluation of Helicobacter pylori inosine 5′-monophosphate dehydrogenase (HpIMPDH) inhibitors. Further optimization of selectivity towards HpIMPDH over human IMPDH2

Inosine 5′-monophosphate dehydrogenase (IMPDH, EC 1.1.1.205) catalyzes a crucial step in guanine nucleotide biosynthesis, thereby governing cell proliferation. In contrast to mammalian IMPDHs, microbial IMPDHs are relatively less explored as potential tar

Design, synthesis, and biological evaluation of Helicobacter pylori inosine 5′-monophosphate dehydrogenase (HpIMPDH) inhibitors

Inosine 5′-monophosphate dehydrogenase (IMPDH) catalyzes a crucial step in the biosynthesis of guanine nucleotides. Being a validated target for immunosuppressive, antiviral, and anticancer drug development, lately it has been exploited as a promising target for antimicrobial therapy. Extending our previous work on Mycobacterium tuberculosis IMPDH, GuaB2, inhibitor development, we screened a set of 23 new chemical entities (NCEs) with substituted flavone (Series 1) and 1,2,3-triazole (Series 2) core structures for their in vitro Helicobacter pylori IMPDH (HpIMPDH) and human IMPDH2 (hIMPDH2) inhibitory activities. All the NCEs possessed acceptable molecular, physicochemical, and toxicity property profiles. The ranges for HpIMPDH and hIMPDH2 inhibition were 9–99.9% and 16–57%, respectively, at 10 μM concentration. The most potent HpIMPDH inhibitor, 25c, exhibited IC50 value of 1.27 μM with no hIMPDH2 inhibitory activity. The moderately potent, structurally novel hit molecule, 25c, may serve as a lead for further design and development of highly potent HpIMPDH inhibitors.

(3Z)-3-(2,3-dihydro-1H-inden-1-ylidene)-1,3-dihydro-2H-indol-2-ones as kinase inhibitors

The present invention relates to organic molecules capable of modulating tyrosine kinase signal transduction in order to regulate, modulate and/or inhibit abnormal cell proliferation.