613-84-3

Basic information

• Product Name: 5-Methylsalicylaldehyde
• Synonyms: 2-hydroxy-5-methyl-benzaldehyd;ASISCHEM D29246;2,5-CRESOTALDEHYDE;2-HYDROXY-5-METHYLBENZALDEHYDE;2-HYDROXY-5-METHYLSALICYLALDEHYDE;5-METHYLSALICYLALDEHYDE;2-Hydroxy-5-Methylbenzaldehyde (5-Methoxysalicylaldehyde);Benzaldehyde, 2-hydroxy-5-methyl-
• CAS NO: 613-84-3
• Molecular Formula: C₈H₈O₂
• Molecular Weight: 136.15
• EINECS: 210-357-6
• Product Categories: Aromatic Aldehydes & Derivatives (substituted);Aldehydes;Building Blocks;C8;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 613-84-3.mol
• Article Data: 75

Chemical Properties

• Melting Point: 54-57 °C(lit.)
• Boiling Point: 217 °C(lit.)
• Flash Point: 85.1 °C
• Appearance: Pale yellow to yellow/Crystalline Powder
• Density: 1.0913
• Vapor Pressure: 0.09mmHg at 25°C
• Refractive Index: 1.5470 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• PKA: 8.47±0.18(Predicted)
• BRN: 2040673
• CAS DataBase Reference: 5-Methylsalicylaldehyde(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Methylsalicylaldehyde(613-84-3)
• EPA Substance Registry System: 5-Methylsalicylaldehyde(613-84-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 613-84-3(Hazardous Substances Data)

Usage

Uses

2-Hydroxy-5-methylbenzaldehyde is used in preparation of novel 2-Phenylcyclopropanamine derivatives as Lysine-specific Demethylase 1 inhibitors (LSD1-inhibitors) for prevention or treatment of primary brain tumor.

InChI:InChI=1/C8H8O2/c1-6-2-3-8(10)7(4-6)5-9/h2-5,10H,1H3

Upstream product

• 106-44-5 p-cresol 
• 302-17-0 chloral hydrate 
• 74-90-8 hydrogen cyanide 
• 67-66-3 chloroform 
• 4383-07-7 2-hydroxymethyl-4-methylphenol 
• 100-97-0 hexamethylenetetramine 
• 298-12-4 Glyoxilic acid 
• 76-03-9 trichloroacetic acid 
• 50-00-0 formaldehyd 
• 123-08-0 4-hydroxy-benzaldehyde 
• 13460-50-9 metaboric acid 
• 56-81-5 glycerol 
• 25458-49-5 1-(methoxymethoxy)-4-methylbenzene 
• 110-54-3 hexane 

Downstream Products

• 106052-71-5 2-hydroxy-5-methyl-benzaldehyde-[2]pyridylimine 
• 61313-36-8 5'-chloro-2,2'-dihydroxy-5-methyl-trans-chalcone 
• 10242-13-4 6-methyl-2-oxo-2H-chromene-3-carboxylic acid 
• 77117-15-8 6-methyl-3-acetyl coumarin 
• 23000-31-9 6-methyl-3-phenylcoumarin 
• 327613-95-6 3-benzoyl-6-methyl-2H-chromen-2-one 
• 19430-16-1 5-methyl-salicylidene-p-methylaniline 
• 110252-72-7 4-methyl-2-(6-methyl-[2]quinolyl)-phenol 
• 53389-98-3 2-(benzyloxy)-5-methylsalicylaldehyde 
• 20771-86-2 2-[(4-Methoxy-phenylimino)-methyl]-5-methyl-phenol 
• 88521-64-6 2-formyl-4-methylphenoxyacetic acid 
• 88521-73-7 ethyl 2-(2-formyl-4-methylphenoxy)acetate 
• 10242-09-8 5-methylbenzofuran-2-carboxylic acid 
• 6943-13-1 bis-(5-methyl-salicylidene)-ethylenediamine 

Relevant articles and documents

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Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: Access to the synthesis of chromeno[4,3-: B] pyrroles

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates with aldimine esters has been developed to provide a series of chromeno[4,3-b]pyrrole derivatives that contain three contiguous stereogenic centers. The method gives a good yield, excellent chemoselectivity and diastereoselectivity under mild conditions.

Highly practical and efficient preparation of aldehydes and ketones from aerobic oxidation of alcohols with an inorganic-ligand supported iodine catalyst

Herein, we divulge an efficient protocol for aerobic oxidation of alcohols with an inorganic-ligand supported iodine catalyst, (NH4)5[IMo6O24]. The catalyst system is compatible with a wide range of groups and exhibits high selectivity, and shows excellent stability and reusability, thus serving as a potentially greener alternative to the classical transformations.