613-94-5Relevant articles and documents
Highly selective colorimetric fluorescent sensor for Pb2+
Goswami, Shyamaprosad,Chakrabarty, Rinku
, p. 3791 - 3795 (2010)
Phenanthroline-based colorimetric sensors 1 and 2 have been designed, synthesized, and compared with phenanthrene-based receptor 3 for sensing of Pb2+ by color change. Receptor 1 imparts color change (from yellow to red) selectively with Pb2+ in acetonitrile/water (9:1) as well as in methanol/water (9:1) when in the presence of other metal ions studied (Li +, Na+, K+, Ca2+, Mg2+, Ba2+, Fe3+, Co2+, Ni2+, Cu 2+, Zn2+, Cd2+, Hg2+, and Mn 2+ as their Perchlorate salts). Receptor 1 also shows fluorescence enhancement upon addition of lead Perchlorate in acetonitrile/water (9:1) solvent possibly due to the chelation enhanced fluorescence (CHEF) effect. However, the binding behavior of 2 with Pb2+ is found to be less effective compared to that of receptor 1.
Synthesis, characterization, thermal degradation and urease inhibitory studies of the new hydrazide based Schiff base ligand 2-(2-hydroxyphenyl)-3-{[(E)-(2-hydroxyphenyl)methylidene]amino}-2,3-dihydroquinazolin-4(1H)-one
Ikram, Muhammad,Rehman, Sadia,Subhan, Fazle,Akhtar, Muhammad Nadeem,Sinnokrot, Mutasem Omar
, p. 308 - 319 (2017)
The novel Schiff base ligand 2-(2-hydroxyphenyl)-3-{[(E)-(2-hydroxyphenyl)methylidene]amino}-2,3-dihydroquinazolin-4(1H)-one (H-HHAQ) derived from 2-aminobenzhydrazide was synthesized and characterized by elemental analyses, ES+-MS, 1/sup
A new strategy for fluorometric detection of ascorbic acid based on hydrolysis and redox reaction
Zhao, Yirong,Li, Yinhui,Wang, Yijun,Zheng, Jing,Yang, Ronghua
, p. 35112 - 35115 (2014)
In this study, a near-infrared, indole-cyanine probe, i.e. Cy5-HD, was designed for the detection of ascorbic acid for the first time. The probe has a hydrazone moiety that can be hydrolyzed by Cu2+ to induce the fluorescence quenching of Cy5-H
Protein-Metal-Ion Interactions Studied by Mass Spectrometry-Based Footprinting with Isotope-Encoded Benzhydrazide
Guo, Chunyang,Cheng, Ming,Gross, Michael L.
, p. 1416 - 1423 (2019)
Metal ions, usually bound by various amino-acid side chains in proteins, play multiple roles in protein folding, conformational change, cellular communication, and catalysis. Ca(II) and Mg(II), abundant among biologically relevant cations, execute their c
Exploration of synthesis, structural aspects, DFT studies and bio-efficacy of some new DHA-benzohydrazide based copper(II) complexes
Richa,Kumar, Sunil,Sindhu, Jayant,Choudhary, Poonam,Jaglan, Sundeep,Zangrando, Ennio,Kumar, Rakesh,Sahoo, Subash C.,Kumar, Vinod,Mehta, Surinder K.,Kataria, Ramesh
, (2021)
A copper (II) complex with ligand obtained by the dehydrative condensation of 3-acetyl-6-methyl-2H-pyran-2,4(3H)?dione (DHA) and benzohydrazide has been synthesized (4). This species was additionally coordinated by various solvent molecules, namely ethano
Pleuromutilin derivative with 1, 3, 4-oxadiazole side chain and preparation and application thereof
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Paragraph 0055-0056; 0070; 0090; 0093; 0095; 0102, (2021/07/24)
The invention belongs to the field of medicinal chemistry, and particularly relates to a pleuromutilin derivative with a 1, 3, 4-oxadiazole side chain and preparation and application thereof The pleuromutilin derivative with the 1, 3, 4-oxadiazole side chain is a compound shown in a formula 2 or a pharmaceutically acceptable salt thereof, and a solvent compound, an enantiomer, a diastereoisomer and a tautomer of the compound shown in the formula 2 or the pharmaceutically acceptable salt thereof or a mixture of the solvent compound, the enantiomer, the diastereoisomer and the tautomer in any proportion, including a racemic mixture. The pleuromutilin derivative has good antibacterial activity, is especially suitable for being used as a novel antibacterial agent for systemic system infection of animals or human beings, and has good water solubility.
Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles
Bai, Hangyu,Jiang, Weiqi,Li, Qi,Li, Tian,Ma, Shichuang,Shi, Baojun,Wu, Wenjun
, p. 11572 - 11581 (2021/10/12)
A series of novel steroidal derivatives with a substituted 1,3,4-oxadiazole structure was designed and synthesized, and the target compounds were evaluated for their insecticidal activity against five aphid species. Most of the tested compounds exhibited potent insecticidal activity against Eriosoma lanigerum (Hausmann), Myzus persicae, and Aphis citricola. Compounds 20g and 24g displayed the highest activity against E. lanigerum, showing LC50 values of 27.6 and 30.4 μg/mL, respectively. Ultrastructural changes in the midgut cells of E. lanigerum were detected by transmission electron microscopy, indicating that these steroidal oxazole derivatives might exert their insecticidal activity by destroying the mitochondria and nuclear membranes in insect midgut cells. Furthermore, a field trial showed that compound 20g exhibited effects similar to those of the positive controls chlorpyrifos and thiamethoxam against E. lanigerum, reaching a control rate of 89.5% at a dose of 200 μg/mL after 21 days. We also investigated the hydrolysis and metabolism of the target compounds in E. lanigerum by assaying the activities of three insecticide-detoxifying enzymes. Compound 20g at 50 μg/mL exhibited inhibitory action on carboxylesterase similar to the known inhibitor triphenyl phosphate. The above results demonstrate the potential of these steroidal oxazole derivatives to be developed as novel pesticides.
