6131-90-4

Basic information

• Product Name: Sodium acetate trihydrate
• Synonyms: SODIUM ACETATE 3H2O;SODIUM ACETATE-3-HYDRATE;SODIUM ACETATE TRIHYDRATE;SODA CAUSTIC;ACETIC ACID SODIUM SALT TRIHYDRATE;Natriumacetat-trihydrat;sodiumethanoatetrihydrate;Acetic acid, sodium salt trihydrate, for analysis, 99.5%
• CAS NO: 6131-90-4
• Molecular Formula: C₂H₃NaO₂*3H₂O
• Molecular Weight: 136.08
• EINECS: 204-823-8
• Product Categories: INORGANIC & ORGANIC CHEMICALS;Inorganic Chemicals;API;mordant dyes;Food additive;printing and dyeing;Organic chemistry;Food Additives
• Mol File: 6131-90-4.mol
• Article Data: 0

Chemical Properties

• Melting Point: 58 °C
• Boiling Point: >400°C
• Flash Point: >250°C
• Appearance: White tranparent/Solid
• Density: 1,45 g/cm3
• Storage Temp.: Store at RT.
• Solubility: H2O: 3 M at 20 °C, clear, colorless
• PKA: 4.76 (acetic acid)(at 25℃)
• Water Solubility: 762 g/L (20 ºC)
• Stability: Stable. Incompatible with strong oxidizing agents, halogens.
• Merck: 14,8571
• BRN: 3732037
• CAS DataBase Reference: Sodium acetate trihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Sodium acetate trihydrate(6131-90-4)
• EPA Substance Registry System: Sodium acetate trihydrate(6131-90-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 24/25-36-26
• WGK Germany: 1
• RTECS: AJ4580000
• TSCA: Yes
• Hazardous Substances Data: 6131-90-4(Hazardous Substances Data)

Usage

Chemical Properties

Sodium acetate trihydrate is the trihydrate sodium salt oaf acetic acid. It is a colorless, odorless crystals that can be weathered in the air. Soluble in water and ether, pH of 0.1M aqueous solution is 8.9. moderately soluble in ethanol, 5.3 g/100mL. Anhydrous Sodium acetate occurs as colorless, transparent crystals or a granular crystalline powder with a slight acetic acid odor.

Uses

Sodium acetate trihydrate is used in various applications. It is used as a buffer of a pH range in between to 4.0 to 6.0. It is also used in the purification and precipitation of nucleic acids and in protein crystallization. It is used as a mordant dyeing, as a pickling agent in chrome tanning, as a neutralizer in waste streams containing sulfuric acid, in the textile industry and as a photoresist while using aniline dyes. It plays an important role to retard vulcanization of chloroprene in synthetic rubber production. It is a precursor to prepare ester from alkyl halide. Other applications are in photography, as an additive to food, in purification of glucose, in preservation of meat, in tanning, and as a dehydrating agent. In analytical chemistry it is used to prepare buffer solution.

General Description

Sodium acetate trihydrate can be obtained from the crystallization of sodium acetate in water. On heating at 75°C, it melts, while on heating above 120°C it loses water of crystallization and gets converted into anhydrous form. The hyperfine proton and 13C splittings have been evaluated by recording ESR spectra of its irradiated single crystals. ESR studies suggested the existence of trapped methyl radicals. Its crystals are monoclinic and its crystal structure has been investigated by photographic methods. Unit cell parameters were evaluated.

Pharmaceutical Applications

Sodium acetate is used as part of a buffer system when combined with acetic acid in various intramuscular, intravenous, topical, ophthalmic, nasal, oral, otic, and subcutaneous formulations. It may be used to reduce the bitterness of oral pharmaceuticals. It can be used to enhance the antimicrobial properties of formulations; it has been shown to inhibit the growth of S. aureus and E. coli, but not C. albicans in protein hydrolysate solutions. It is widely used in the food industry as a preservative. Sodium acetate has also been used therapeutically for the treatment of metabolic acidosis in premature infants, and in hemodialysis solutions.

Biochem/physiol Actions

Sodium acetate trihydrate (SAT) is a phase change material (PCM) that can be easily combined with the preparation of domestic hot water, space heating, solar heating, and radiant floor heating systems. The hydrated salt of SAT possesses high latent heat density and thus can be used for low-temperature heat storage.

Safety

Sodium acetate is widely used in cosmetics, foods, and pharmaceutical formulations, and is generally regarded as a nontoxic and nonirritant material. A short-term feeding study in chickens with a diet supplemented with 5.44% sodium acetate showed reduced growth rates that were attributed to the sodium content.(9) Sodium acetate is poisonous if injected intravenously, is moderately toxic by ingestion, and is an irritant to the skin and eyes. LD50 (rat, oral): 3.53 g/kg LD50 (mouse, IV): 0.38 g/kg LD50 (mouse, SC): 8.0 g/kg

storage

Sodium acetate should be stored in airtight containers.

Incompatibilities

Sodium acetate reacts with acidic and basic components. It will react violently with fluorine, potassium nitrate, and diketene.

Regulatory Status

GRAS listed. Accepted as a food additive in Europe. Included in the FDA Inactive Ingredients Database (injections, nasal, otic, ophthalmic, and oral preparations).

References

[1] http://www.europlat.org [2] http://www.rxlist.com/sodium-acetate-drug.htm [3] http://cosmetics.specialchem.com [4] http://cecri.csircentral.net/2710/1/036-96.pdf

InChI:InChI=1/C2H4O2.Na.3H2O/c1-2(3)4;;;;/h1H3,(H,3,4);;3*1H2/q;+1;;;/p-1

Synthetic route

acetic acid (64-19-7) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
With sodium carbonate

sodium acetate (127-09-3) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
With water In neat (no solvent) formation of supersaturated soln. via H2O uptake, solidification after contact with solid materials and slow formation of NaCH3CO2*3H2O;;
With water in moist air at ambient temp.;;
With H2O in moist air at ambient temp.;;
With H2O In neat (no solvent) formation of supersaturated soln. via H2O uptake, solidification after contact with solid materials and slow formation of NaCH3CO2*3H2O;;

water (7732-18-5) + sodium acetate (127-09-3) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
In neat (no solvent) equlibrium reaction, uptake of 3 mol H2O from moist air;;
In neat (no solvent) equlibrium reaction, uptake of 3 mol H2O from moist air;;

acetic acid (64-19-7) + sodium chloride (7647-14-5) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
With copper(I) oxide In neat (no solvent) byproducts: HCl; reaction without influence of air via stirring NaCl with acetic acid in presence of Cu2O;;
With Cu2O In neat (no solvent) byproducts: HCl; reaction without influence of air via stirring NaCl with acetic acid in presence of Cu2O;;

sodium carbonate (497-19-8) + acetic acid (64-19-7) + sodium hydroxide (1310-73-2) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
In neat (no solvent) addition of solid NaOH to soln. of acetic acid and Na2CO3 yileds yellow crystalls;; via recrystallization;;
In neat (no solvent) addition of solid NaOH to soln. of acetic acid and Na2CO3 yileds yellow crystalls;; via recrystallization;;

sodium carbonate (497-19-8) + acetic acid (64-19-7) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
react. of glacial acetic acid (distd. over CrO3, storage over Br2, distd. over KMnO4) and Na2CO3 ( several times recrystn. from soln. containing hypobromite);; fractionated crystn.; very pure product;;
react. of glacial acetic acid (distd. over CrO3, storage over Br2, distd. over KMnO4) and Na2CO3 ( several times recrystn. from soln. containing hypobromite);; fractionated crystn.; very pure product;;

acetamide (60-35-5) + sodium hydroxide (1310-73-2) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
In neat (no solvent) byproducts: NH3;
In neat (no solvent) byproducts: NH3;

barium(II) acetate (543-80-6) + sodium carbonate (497-19-8) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
In neat (no solvent)
In neat (no solvent)

ethyl acetate (141-78-6) + sodium hydroxide (1310-73-2) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
In water byproducts: alcohol; saponification of CH3CO2C2H5 with solid NaOH in presence of H2O or in presence of NaCH3CO2*3H2O or its concd. soln.;;
In water byproducts: alcohol; saponification of CH3CO2C2H5 with solid NaOH in presence of H2O or in presence of NaCH3CO2*3H2O or its concd. soln.;;

methanol (67-56-1) + carbon monoxide (201230-82-2) + sodium hydroxide (1310-73-2) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
In neat (no solvent) reaction of CH3OH with CO or CO containing gases at 200 to 300°C and small excess NaOH;;
In neat (no solvent) reaction of CH3OH with CO or CO containing gases at 200 to 300°C and small excess NaOH;;
In neat (no solvent) reaction of CH3OH with CO or CO containing gases at 200 to 300°C and small excess NaOH;;

methanol (67-56-1) + carbon monoxide (201230-82-2) + sodium carbonate (497-19-8) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
In neat (no solvent) reaction of CH3OH with CO or CO containing gases at 200 to 300°C and small excess Na2CO3;;
In neat (no solvent) reaction of CH3OH with CO or CO containing gases at 200 to 300°C and small excess Na2CO3;;
In neat (no solvent) reaction of CH3OH with CO or CO containing gases at 200 to 300°C and small excess Na2CO3;;

methanol (67-56-1) + sodium formate (141-53-7) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
With water In neat (no solvent) heating NaHCO2 in autoclave to 200 to 300°C unnder pressure in presence of little H2O while treating with CH3OH vapor;;
With H2O In neat (no solvent) heating NaHCO2 in autoclave to 200 to 300°C unnder pressure in presence of little H2O while treating with CH3OH vapor;;
With water In neat (no solvent) heating NaHCO2 in autoclave to 200 to 300°C unnder pressure in presence of little H2O while treating with CH3OH vapor;;

sodium acetate (127-09-3) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
With water
With H2O

sodium acetate acetic acid (97984-89-9) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
With H2O In neat (no solvent) in moist air;;

sodium acetate (127-09-3) → sodium acetate trihydrate (6131-90-4)

Conditions	Yield
With H2O

C37H55N9O9S2Si2 + sodium acetate trihydrate (6131-90-4) → Me2N-Arg(Teoc)2-Thz-MeOxz-Thz-MeOxz-OMe (1455474-92-6)

Conditions	Yield
Stage #1: C37H55N9O9S2Si2; sodium acetate trihydrate With formaldehyd In tetrahydrofuran; water at 0℃; for 0.0833333h; Inert atmosphere; Stage #2: With sodium cyanoborohydride In tetrahydrofuran; water at 0℃; for 1h; Inert atmosphere;	99%

CH(O)C6H2(CH3)(CO)ORh(P(C6H5)3)2Cl (222532-70-9) + sodium acetate trihydrate (6131-90-4) → CH(O)C6H2(CH3)(CO)ORh(P(C6H5)3)2OOCCH3 (222532-65-2)

Conditions	Yield
In dichloromethane; water; acetone stirring (0.5 h), evapn.; filtering, washing (H2O), drying (vac.);	98%

cis-[Ru(NO)(H2O)((C5H4N)2)2](ClO4)3*3H2O + sodium acetate trihydrate (6131-90-4) → cis-[Ru(NO)(OCOCH3)((C5H4N)2)2](ClO4)2*H2O

Conditions	Yield
With NaClO4 In water addn. of CH3COONa to aq. Ru complex soln., adjusting ph to 4 with few drops of CH3COOH, heating soln to 70°C, 0.5 h, cooling, addn. of NaClO4; pptn., storage in a refrigerator overnight, filtration, washing (MeOH, ether), air-drying; elem. anal.;	95%

CH3C6H4NCHC6H2(CH3)(CO)OHRh(P(C6H5)3)2Cl2 + sodium acetate trihydrate (6131-90-4) → CH(O)C6H2(CH3)(CO)ORh(P(C6H5)3)2OOCCH3 (222532-65-2)

Conditions	Yield
In dichloromethane; water; acetone NaOAc soln. (H2O) addn., stirring (0.5 h), evapn. (reduced pressure); filtering, washing (H2O), drying (vac.);	93%

C60H66O16 + sodium acetate trihydrate (6131-90-4) → C60H68N2O16

Conditions	Yield
With hydroxylamine chloride In tetrahydrofuran for 3h;	93%

tris(triphenylphosphine)ruthenium(II) chloride (15529-49-4, 41756-81-4) + sodium acetate trihydrate (6131-90-4) → RuCl(OAc)(PPh3)3 (55978-89-7)

Conditions	Yield
In tert-butyl alcohol Ru-complex and AcONa*3H2O were intimately ground together in a mortar and pestle in air, mixt. was exposed to vac. for 30 min, flask filled with Ar, t-BuOH added, solm. was refluxed with rapid stirring for 1 h; ppt. was isolated by filtration in air, washed successively with Et2O, water, MeOH, Et2O, dried under reduced pressure; elem. anal.;	92%

bis(ethylene)rhodium(I) chloride dimer + sodium acetate trihydrate (6131-90-4) → di-μ-acetatotetrakis(dihaptoethene)dirhodium(I) (88411-47-6)

Conditions	Yield
In diethyl ether (argon); stirring (-30°C to room temp., 1 h); filtration, evapn. (vac.), recrystn. (pentane); elem. anal.;	92%

sodium diphenylphosphinobenzene-m-monosulfonate dihydrate + [RuCl2((C6H5)2P(m-C6H4SO3Na))2] * 4H2O + sodium acetate trihydrate (6131-90-4) → [HRu(OAc)((C6H5)2P(m-C6H4SO3Na))2] * 6H2O

Conditions	Yield
With hydrogen In ethanol H2-atmosphere; molar ratio Ru-complex:ligand:NaOAc=1:1:2, refluxing (16h); cooling (pptn.), filtration, washing (acetone); elem. anal.;	90%

2-Hydroxy-1,4-naphthoquinone (83-72-7) + copper(II) acetate monohydrate (6046-93-1) + sodium acetate trihydrate (6131-90-4) → [Cu(OC10H5O2)2(H2O)]2

Conditions	Yield
With orthoformic acid triethyl ester In methanol dissol. of Cu salt in MeOH, addn. of triethylorthoformate, purging with N2, addn. of soln. of lawsone in MeOH/triethylorthoformate, purging withN2, stirring (in N2 atmosphere, 15 min), addn. of NaOAc in MeOH to pH = 6, pptn.; filtration, washing (MeOH, Et2O), drying (vac.); elem. anal.;	90%

methanol (67-56-1) + vanadyl(IV) sulphate pentahydrate + sodium acetate trihydrate (6131-90-4) + salicylaldehyde (90-02-8) + (R)-3-bromoalanine methyl ester hydrobromide → [VO(MeOH)4](2+) + [VO(sal-BrAlaMe)MeOH][acetate]*H2O

Conditions	Yield
In tetrahydrofuran; methanol (O2-free solvents); VOSO4*5H2O and NaCH3COO*3H2O dissolved in MeOH, treated with a THF soln. of HOC6H4CHO, a MeOH soln. of (BrCH2CH(NH3)COOCH3)Br added dropwise, stirred at room temp. overnight in the dark; filtered under inert atmosphere, evapd. (vac.); elem. anal.;	A n/a B 90%

sodium acetate trihydrate (6131-90-4) + acetic acid (64-19-7) + 2-Bromo-4'-methoxyacetophenone (2632-13-5) → p-methoxyphenacyl acetate (58518-78-8)

Conditions	Yield
In ethanol; water for 2.5h; Reflux;	90%

(μ-acetato-O,O')(N,N',N''-tris((N-methyl-2-benzimidazolyl)methyl)-N'-methyl-1,3-diamino-2-propanolato)copper(II) perchlorate * 5.5H2O + sodium acetate trihydrate (6131-90-4) + bis(triphenylphosphorylidene)ammonium azide (38011-36-8) → bis[(μ-acetato-O,O')(N,N',N''-tris((N-methyl-2-benzimidazolyl)methyl)-N'-methyl-1,3-diamino-2-propanolato)dicopper(II)]-μ-1,3-azide perchlorate * 8.5H2O

Conditions	Yield
In acetonitrile byproducts: (PPN)ClO4; stoich. amts., stirring (room temp., 4 h); crystn. on vapor diffusion of ether, collection, washing (ether); elem.anal.;	89.2%

3,5-dimethyl-1H-pyrazole (67-51-6) + nickel(II) nitrate hexahydrate + sodium acetate trihydrate (6131-90-4) → [Ni(3,5-dimethylpyrazole)2(CH3COO)(H2O)3]NO3·2H2O

Conditions	Yield
In water at 20℃; for 2h;	89%

3,5-dimethyl-1H-pyrazole (67-51-6) + nickel(II) chloride hexahydrate + sodium acetate trihydrate (6131-90-4) → [Ni(3,5-dimethylpyrazole)2(CH3COO)(H2O)3]Cl

Conditions	Yield
In water at 20℃; for 2h;	87.2%

Ru(2+)*2Cl(1-)*C6H5P((CH2)3P(C6H5)2)2=RuCl2(C6H5P((CH2)3P(C6H5)2)2) + sodium acetate trihydrate (6131-90-4) → RuCl(O2CCH3)(bis(3-(diphenylphosphino)propyl)phenylphosphine) (84623-44-9)

Conditions	Yield
In tetrahydrofuran soln. of complex and excess NaOCOCH3*3H2O refluxed for 3 h; concd. (vac.), ether added, solid collected, washed with H2O, EtOH, ether, dried (vac.); elem. anal.;	87%

[IrH2Cl(PiPr3)2] (149253-45-2, 115116-30-8, 99920-04-4, 141040-31-5) + sodium acetate trihydrate (6131-90-4) → [IrH2(OCOCH3)(P(C3H7)3)2] (178665-12-8)

Conditions	Yield
In diethyl ether (argon); stirring (room temp., 15 h); filtration, solvent removal; elem. anal.;	87%

[(η(5)-semiquinone)Mn(CO)3] (178306-23-5) + sodium acetate trihydrate (6131-90-4) → Na[(η(4)-quinone)Mn(CO)3]*3H2O

Conditions	Yield
In dimethyl sulfoxide to soln. of Mn complex in DMSO added NaOAc*3H2O under N2 at room temp.; after 20 min pptd. by acetone; washed (acetone); elem. anal.;	85%

di-μ-chlorotetrakis(η2-ethylene)diiridium(I) + sodium acetate trihydrate (6131-90-4) → [Ir(C2H4)2(OCOCH3)]2 (88411-53-4)

Conditions	Yield
In diethyl ether (argon); stirring (-78 to 0°C, 30 min), recooling to -78°C, kept under 0.5 bar ethene, slow warming to 0°C, repeating the procedure 3x, finally warming to room temp.; solvent removal, extn. (pentane), pptn. upon concn. (vac.), yield is for2 steps; elem. anal.;	85%

4-methoxypyridine (620-08-6) + cobalt(II) nitrate hexahydrate + dihydrogen peroxide (7722-84-1) + sodium acetate trihydrate (6131-90-4) → Co4O4(O2CMe)4(4-OMepy)4

Conditions	Yield
In methanol for 4h; Reflux;	85%

vanadyl(IV) sulphate pentahydrate + xanthurenic acid (59-00-7) + sodium acetate trihydrate (6131-90-4) → {VO(8-oxy-4-hydroxychinoline-2-carboxylate)(H2O)} (158403-58-8)

Conditions	Yield
In water N2; stirring for 3 h at 80 ° C and overnight at room temperature;; filtration; washing with water; elem. anal.;;	84%

copper(II) perchlorate hydrate + N,N',N''-tris((N-methyl-2-benzimidazolyl)methyl)-N'-methyl-1,3-diamino-2-propanol hydrate + sodium acetate trihydrate (6131-90-4) → (μ-acetato-O,O')(N,N',N''-tris((N-methyl-2-benzimidazolyl)methyl)-N'-methyl-1,3-diamino-2-propanolato)copper(II) perchlorate * 5.5H2O

Conditions	Yield
In methanol pptn. on mixing stoich. amts., stirring (room temp., 30 min); cooling to -20°C overnight, collection (filtration), washing (cold MeOH), drying in air, recrystn. (vapor diffusion of ether into MeCN soln.), collection, drying in air; elem. anal.;	84%

tetrahydrofuran (109-99-9) + methyl 5-((1,2:3,4-di-O-isopropylidene-α-D-galactosyl)oxycarbonyl)-2-pyridinecarboxylate (944456-42-2) + vanadyl(IV) sulphate pentahydrate + sodium acetate trihydrate (6131-90-4) → [bis(5-((1,2:3,4-di-O-isopropylidene-α-D-galactosyl)oxycarbonyl)-2-pyridinecarboxylate)(tetrahydrofuran)oxovanadium(IV)]-tetrahydrofuran-sodium sulfate (1/3/0.75)

Conditions	Yield
In tetrahydrofuran; water stoich., a soln. of N compd. and Na compd. (THF/water) mixed with a soln. of V compd. (water), refluxed for ca. 6 h; solvent evapd., residue dissolved (THF), filtered, evapd. to dryness; elem. anal.;	84%

pyridine-4-carbonitrile (100-48-1) + cobalt(II) nitrate hexahydrate + dihydrogen peroxide (7722-84-1) + sodium acetate trihydrate (6131-90-4) → CoIII4(μ3-O)4(μ-O2CCH3 )4(4-CNpy)4 (935536-80-4)

Conditions	Yield
In methanol for 4h; Reflux;	84%

copper(II) perchlorate hexahydrate + sodium acetate trihydrate (6131-90-4) + N,N,N'-tris-(2-pyridylmethyl)-1,3-diaminopropan-2-ol (276867-57-3) → Cu2(N,N,N'-tris-(2-pyridylmethyl)-1,3-diaminopropan-2-ol)(OAc)(ClO4)2

Conditions	Yield
In methanol MeOH soln. of ligand and NaOAc*3H2O was added to MeOH soln. of Cu-complex, allowed to stand at 10°C for 1 wk; filtered off; elem. anal.;	83%

2,2,4,4,6,6-hexachloro-1,3,5-triaza-2,4,6-triphosphorine (940-71-6) + sodium acetate trihydrate (6131-90-4) → sodium trimetaphoshimate tetrahydrate

Conditions	Yield
In 1,4-dioxane; water byproducts: H2O, NaCl, CH3CO2H; addn. of aq. soln. of NaO2CCH3 to dioxane soln. of (PNCl2)3 with stirring, stirring (60°C, 24 h); filtration, washing (EtOH, acetone), fractional recrystn. (water/EtOH);	83%

di-μ-chloro-bis[bis(cyclo-octene)rhodium] + sodium acetate trihydrate (6131-90-4) → [Rh(C8H14)2(OCOCH3)]2 (178665-09-3)

Conditions	Yield
In diethyl ether (argon); -30°C to room temp., stirring (6 h); filtration, evapn. (vac.), recrystn. (pentane); elem. anal.;	83%

RuCl2(phenylvinylidene)(triisopropylphosphane)2 + sodium acetate trihydrate (6131-90-4) → [RuCl2(κ2-O2CCH3)(=C=CHPh)(PiPr3)2] (310463-12-8)

Conditions	Yield
In tetrahydrofuran under Ar atm. soln. dichloro(vinylidene)ruthenium complex in THF was treated with CH3COONa*3H2O and stirred for 22 h at room temp.; solvent was removed, residue was extd. with Et2O, extract was evapd. in vacuo, residue was washed with pentane at -78°C and dried; elem.anal.;	82%

iron(III) perchlorate hydrate + 2,6-bis{[(2-hydroxybenzyl)(2-pyridylmethyl)amino]methyl}-4-t-butylphenol + sodium acetate trihydrate (6131-90-4) → C42H45Fe2N4O7(1+)*ClO4(1-)

Conditions	Yield
In methanol at 40℃; for 0.166667h; Glovebox; Inert atmosphere;	82%

praseodymium(III) nitrate hexahydrate + 1,10-phenanthroline hydrate + sodium acetate trihydrate (6131-90-4) → Pr(3+)*C12H8N2*3CH3COO(1-)

Conditions	Yield
In ethanol byproducts: sodium nitrate; phenanthroline is added to the rare earth acetate soln. prepared at the first step; 24 h standing; washing with alcohol, drying in vac.;	80%
In ethanol byproducts: sodium nitrate; phenanthroline is added to the rare earth acetate soln. prepared at the first step; 24 h standing; washing with alcohol, drying in vac.;	80%

N-salicylidene-butylamine (2565-54-0) + sodium acetate trihydrate (6131-90-4) + palladium dichloride → bis(N-butylsalicylideneaminato)palladium(II) (14363-25-8)

Conditions	Yield
With potassium chloride In water; acetone dissoln. of PdCl2 in hot aq. KCl, addn. of NaAc*3H2O, addn. to soln. of org. compd. in acetone, refluxing (30 min), cooling (room temp.); removal of acetone (vac.), filtration, washing (MeOH), recrystn. (EtOH-benzene); elem. anal.;	80%

Upstream product

• 127-09-3 sodium acetate 
• 7732-18-5 water 
• 64-19-7 acetic acid 
• 7647-14-5 sodium chloride 
• 67-56-1 methanol 
• 201230-82-2 carbon monoxide 
• 497-19-8 sodium carbonate 
• 127-09-3 sodium acetate 
• 97984-89-9 sodium acetate acetic acid 
• 127-09-3 sodium acetate 
• 141-53-7 sodium formate 
• 1310-73-2 sodium hydroxide 
• 141-78-6 ethyl acetate 
• 543-80-6 barium(II) acetate 

Downstream Products

• 74-84-0 ethane 
• 74-85-1 ethene 
• 108-24-7 acetic anhydride 
• 138555-65-4 [(2,6-(dichloro)-4-(methylsulfonyl)-phenyl)hydrazono]propanedinitrile 
• 150478-89-0 2-n-Butyl-1-[4-[(α-ethoxycarbonyl)benzylamino]-benzyl]benzimidazole 
• 441713-62-8 methyl (4-amino-2-fluoro-3-hydroxyphenyl)acetate 
• 127-09-3 sodium acetate 
• 543-90-8 cadmium(II) acetate 
• 124081-71-6 2-nitrophenylsulfenyl methyl anthranilate 
• 7732-18-5 water 
• 127-09-3 sodium acetate 
• 127-09-3 sodium acetate 
• 1333-74-0 hydrogen 
• 55978-89-7 RuCl(OAc)(PPh₃)3