61336-70-7

Basic information

• Product Name: Amoxicillin trihydrate
• Synonyms: AmoxycillinTrihydrateBp98;AmoxicillineTrihydrate;AMOXICILLINE 3-HYDRATE;6-(D-[-]-α-Amino-p-hydroxyphenylacetamido) penicillanic acid trihydrate;4-Thia-1-azabicyclo3.2.0heptane-2-carboxylic acid, 6-(2R)-amino(4-hydroxyphenyl)acetylamino-3,3-dimethyl-7-oxo-, trihydrate, (2S,5R,6R)-;AMOXICILLINTRIHYDRATE,USP;amoxicillin soluble powder70%;4-Thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 6-((amino(4-hydroxyphenyl)acetyl)amino)-3,3-dimethyl-7-oxo-, trihydrate (2S-(2alpha,5alpha,6beta(S*)))-
• CAS NO: 61336-70-7
• Molecular Formula: C₁₆H₁₉N₃O₅S*3H₂O
• Molecular Weight: 419.45
• EINECS: 999-999-2
• Product Categories: Antibiotics for Research and Experimental Use;beta-Lactams (Antibiotics for Research and Experimental Use);Biochemistry;Antibiotic Explorer;beta-Lactam Structure;A;Alphabetic;AM to AQAntibiotics;BactericidalAntibiotics;Chemical Structure;Principle;veterinary medicine,soluble powder;Pharma;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;AMOXIL;Antibacterial spectrum;API;Pyridines
• Mol File: 61336-70-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: >200°C (dec.)
• Boiling Point: 743.2 °C at 760 mmHg
• Flash Point: 403.3 °C
• Appearance: A White CRYSTALLINE powder
• Density: 1.54g/cm3
• Vapor Pressure: 3.39E-23mmHg at 25°C
• Refractive Index: 302 ° (C=0.1, H2O)
• Storage Temp.: 2-8°C
• Solubility: Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides.
• Water Solubility: Soluble in water at 3.4mg/ml.
• Merck: 14,577
• BRN: 7507120
• CAS DataBase Reference: Amoxicillin trihydrate(CAS DataBase Reference)
• NIST Chemistry Reference: Amoxicillin trihydrate(61336-70-7)
• EPA Substance Registry System: Amoxicillin trihydrate(61336-70-7)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 42/43
• Safety Statements: 36-36/37-22
• WGK Germany: 2
• RTECS: XH8300000
• Hazardous Substances Data: 61336-70-7(Hazardous Substances Data)

Usage

Chemical Properties

White to Off-White Solid

Uses

Different sources of media describe the Uses of 61336-70-7 differently. You can refer to the following data:
1. Semi-synthetic antibiotic related to Penicillin. Antibacterial.
2. Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.

Definition

ChEBI: A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.

Therapeutic Function

Antibacterial

Safety Profile

Moderately toxic. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

InChI:InChI=1/C16H19N3O5S/c1-16(2)11(15(23)24)19-13(22)10(14(19)25-16)18-12(21)9(17)7-3-5-8(20)6-4-7/h3-6,9-11,14,20H,17H2,1-2H3,(H,18,21)(H,23,24)/t9-,10-,11+,14?/m1/s1

Upstream product

• 79473-28-2 Sodium; 6-[2-((E)-2-ethoxycarbonyl-1-methyl-vinylamino)-2-(4-hydroxy-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate 

Downstream Products

• 79473-28-2 Sodium; 6-[2-((E)-2-ethoxycarbonyl-1-methyl-vinylamino)-2-(4-hydroxy-phenyl)-acetylamino]-3,3-dimethyl-7-oxo-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylate 
• 61-33-6 penicillin G 
• 859495-92-4 [Fe(amoxicillin)(OH)(H₂O)2] 
• 859496-07-4 [Co(amoxicillin)(H₂O)]Cl 
• 859496-16-5 [Co(amoxicillin)(OH)(H₂O)2] 
• 859495-99-1 [Fe(amoxicillin)(OH)2(H₂O)] 

Relevant articles and documents

Process for preparing aminopenicillins

An improved process for the preparation of α-amino-penicillins from an aqueous solution of a derivative of 6-APA and amide-type Dane salts.

Dane salt and process for preparing aminopenicillins therefrom

Amide-type Dane salts having the formula: STR1 wherein R is a group of the formula: STR2 wherein R2 is hydrogen and R3 is phenyl or substituted phenyl, R1 is cyano or nitro, and M is hydrogen, an alkali metal or a triloweralkylamine are disclosed, as well as a process for preparing α-aminopenicillins from these salts and 6-APA.