61396-67-6

Basic information

• Product Name: 1,2-Propanediol, 3-(2-nitrophenoxy)-
• CAS NO: 61396-67-6
• Molecular Formula: C9H11NO5
• Molecular Weight: 213.19
• Mol File: 61396-67-6.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1,2-Propanediol, 3-(2-nitrophenoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2-Propanediol, 3-(2-nitrophenoxy)-(61396-67-6)
• EPA Substance Registry System: 1,2-Propanediol, 3-(2-nitrophenoxy)-(61396-67-6)

Safety Data

• Hazardous Substances Data: 61396-67-6(Hazardous Substances Data)

Usage

General Description

"1,2-Propanediol, 3-(2-nitrophenoxy)-" is a chemical compound where the nitro group (nitrogen and oxygen atoms) is bonded to the phenol group (ring of carbon atoms), which in turn is bonded to the propylene glycol group (combination of carbon, oxygen and hydrogen atoms). The molecular weight of the compound is noted to be quite high, illustrating a complex chemical structure. This chemical compound is recognized for its potential in various chemical reactions and industrial applications. Notably, its specific chemical structure may allow it to act as an intermediate chemical in the synthesis of more complex compounds. However, like all chemicals, it should be handled with proper safety measures given the potential risks attached with exposure or mishandling.

Upstream product

• 123-91-1 1,4-dioxane 
• 21407-49-8 2-nitrophenyl glycidyl ether 
• 88-75-5 2-hydroxynitrobenzene 
• 96-24-2 3-monochloro-1,2-propanediol 
• 824-38-4 potassium 2-nitrophenoxide 

Downstream Products

• 1186240-98-1 C₁₅H₂₅NO₅Si 
• 80491-49-2 2-(2,3-dihydroxypropoxy)benzene aminium chloride 
• 1186241-04-2 2-[[4-[(4-Methoxy-2,6-dimethyl-phenyl)sulfonyl]-3,4-dihydro-2H-[1,4]benzoxazin-3-yl]-methoxy]-acetic acid 
• 1186241-00-8 C₁₅H₂₅NO₂Si 
• 1186240-99-2 C₁₅H₂₃NO₅Si 
• 1186241-06-4 C₁₆H₁₆ClNO₄S 
• 1186241-02-0 C₁₈H₂₁NO₅S 
• 1186241-07-5 C₂₂H₂₆ClNO₆S 
• 1186241-05-3 C₂₂H₃₀ClNO₄SSi 
• 1186241-03-1 C₂₄H₃₁NO₇S 
• 1186241-01-9 C₂₄H₃₅NO₅SSi 
• 1186240-87-8 N-((1-(2-((4-(4-methoxy-2,6-dimethylphenylsulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-3-yl)methoxy)acetyl)-4-(4-methylpiperazin-1-yl)piperidin-4-yl)methyl)isonicotinamide 
• 1187964-52-8 C₂₂H₂₈F₃NO₄SSi 
• 1187964-01-7 C₂₂H₂₄F₃NO₆S 

Relevant articles and documents

Synthesis and aminopeptidase n inhibiting activity of 3-(nitrophenoxymethyl)-[1,3,2]dioxaborolan-2-OLS and their open analogues

Aminopeptidase N (APN) represents a class of zinc metallopeptidases with broad substrate specifity. This enzyme is involved in control of angioneogenesis in cancer and microvascular conditions. It also serves as a superficial cellular receptor that enables attachment of some viruses including coronaviruses to the host cell. APN takes part also in metabolism of some important neuropeptides. That is why APN can be a promising therapeutic target and compounds which influence its activity interesting potential drugs. Here, synthesis of compounds which in most contain 3-phenoxypropan-1,2 diol moiety and evaluation of their inhibition activity against APN is described. 4-[1-, 2- and 3-(Nitrophenoxymethyl)]-[1,3,2]dioxaborolan-2-ols are novel compounds which have never been previously reported in the literature. 3-(Aminophenoxy)propyl-1,2-diols revealed greater activity than both 3-(nitrophenoxy)propyl-1,2-diols and 3-(nitrophenoxymethyl)-[1,3,2]dioxaborolan-2-ols. A QSAR study revealed a linear correlation between lipophilicity and inhibition activity.

SUBSTITUTED SULFONAMIDE DERIVATIVES

The invention relates to substituted sulfonamide derivatives, processes for the preparation thereof, medicaments containing these compounds and the use of substituted sulfonamide derivatives for the preparation of medicaments.

Substituted Sulfonamide Compounds

Substituted sulfonamide compounds corresponding to formula I: a process for their preparation, pharmaceutical compositions comprising such compounds, and the use of such substituted sulfonamide compounds in pharmaceutical compositions for the treatment of pain or other disorders or diseases that are mediated at least in part by B1R receptors.