614-05-1 Usage
Uses
Different sources of media describe the Uses of 614-05-1 differently. You can refer to the following data:
1. thiamine antagonist
2. Oxythiamine chloride hydrochloride is suitable for use:as a reference standard for calibration curve generation in liquid chromatography-tandem mass spectrometry (LC-MS/MS) for oxythiamine pyrophosphate (OTPP) quantification in red blood cells as a thiamine transport inhibitor in human mammary epithelial cells (HMEC) and breast cancer cell lines in the synthesis of oxythiamineH picrolonate salt
Definition
ChEBI: A hydrochloride obtained by combining oxythiamine chloride with one molar equivalent of hydrochloric acid.
General Description
Oxythiamine is a thiamine antimetabolite and the source through diet is by consuming acidic thiamine rich foods.
Biochem/physiol Actions
Oxythiamine (OT) is a thiamine antagonist. It is a transketolase inhibitor and is employed to study anti-metastatic mechanisms, especially those involving metalloproteinases (MMP). It significantly sensitizes human hepatocellular carcinoma cells (HCC) to sorafenib, favoring tumor suppression.
Check Digit Verification of cas no
The CAS Registry Mumber 614-05-1 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 6,1 and 4 respectively; the second part has 2 digits, 0 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 614-05:
(5*6)+(4*1)+(3*4)+(2*0)+(1*5)=51
51 % 10 = 1
So 614-05-1 is a valid CAS Registry Number.
InChI:InChI=1/C12H15N3O2S.2ClH/c1-8-11(3-4-16)18-7-15(8)6-10-5-13-9(2)14-12(10)17;;/h5,7,16H,3-4,6H2,1-2H3;2*1H
