6141-14-6

Basic information

• Product Name: 2-Chloro-4-methylquinazoline
• Synonyms: 2-Chloro-4-methylquinazoline
• CAS NO: 6141-14-6
• Molecular Formula: C₉H₇ClN₂
• Molecular Weight: 178.6183
• Product Categories: API intermediates
• Mol File: 6141-14-6.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 262.8 °C at 760 mmHg
• Flash Point: 138.2 °C
• Appearance: /
• Density: 1.292g/cm³
• Vapor Pressure: 0.0174mmHg at 25°C
• Refractive Index: 1.643
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.94±0.30(Predicted)
• CAS DataBase Reference: 2-Chloro-4-methylquinazoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chloro-4-methylquinazoline(6141-14-6)
• EPA Substance Registry System: 2-Chloro-4-methylquinazoline(6141-14-6)

Safety Data

• Hazardous Substances Data: 6141-14-6(Hazardous Substances Data)

Usage

General Description

2-Chloro-4-methylquinazoline is a chemical compound that belongs to the class of organic compounds known as quinazolines, a polycyclic aromatic hydrocarbons containing a quinazoline moiety. It is defined by a quinazoline core structure, which is a six-membered aromatic heterocycle made up of two benzene rings connected by a bridging nitrogen and a carbon atom to form a bicyclic structure. The specific compound 2-Chloro-4-methylquinazoline is distinguished by the presence of a chlorine atom at the 2-position and a methyl group at the 4-position of the quinazoline ring. This chemical is used in the synthesis of various pharmacologically active molecules and is commonly employed in pharmaceutical research.

InChI:InChI=1/C9H7ClN2/c1-6-7-4-2-3-5-8(7)12-9(10)11-6/h2-5H,1H3

Upstream product

• 34790-24-4 4-methyl-1,2-dihydro-2-oxoquinazoline 
• 69559-56-4 N-(2-acetylphenyl)-2,2,2-trichloroacetamide 
• 631-61-8 ammonium acetate 
• 551-93-9 2-aminoacetophenone 
• 607-68-1 2,4-dichloroquinazoline 
• 676-58-4 methylmagnesium chloride 
• 75-24-1 trimethylaluminum 

Downstream Products

• 1591672-19-3 3-phenyl-5-(piperidin-1-yl)imidazo[1,5-c]quinazoline 
• 1591672-21-7 4-(3-phenylimidazo[1,5-c]quinazolin-5-yl)morpholine 
• 241819-98-7 1-Methyl-1-(4-methylquinazolin-2-yl)-4-(p-nitrophenyl)thiosemicarbazide 
• 241819-97-6 1-Methyl-1-(4-methylquinazolin-2-yl)-4-(p-ethoxyphenyl)thiosemicarbazide 
• 241819-96-5 1-Methyl-1-(4-methylquinazolin-2-yl)-4(m-methoxyphenyl)thiosemicarbazide 
• 241819-95-4 1-Methyl-1-(4-methylquinazolin-2-yl)-4-(p-methoxyphenyl)thiosemicarbazide 
• 241819-99-8 1-Methyl-1-(4-methyiquinazolin-2-yl)-4-(ethoxycarbonyl)thiosemicarbazide 

Relevant articles and documents

2-Guanidinoquinazolines as new inhibitors of the STAT3 pathway

Synthesis and SAR investigation of 2-guanidinoquinazolines, initially identified in a high content screen for selective STAT3 pathway inhibitors, led to a more potent analog (11c) that demonstrated improved anti-proliferative activity against a panel of HNSCC cell lines.

A novel series of IKKβ inhibitors part I: Initial SAR studies of a HTS hit

A novel series of (E)-1-((2-(1-methyl-1H-imidazol-5-yl) quinolin-4-yl) methylene) thiosemicarbazides was discovered as potent inhibitors of IKKβ. In this Letter we document our early efforts at optimization of the quinoline core, the imidazole and the semithiocarbazone moiety. Most potency gains came from substitution around the 6- and 7-positions of the quinoline ring. Replacement of the semithiocarbazone with a semicarbazone decreased potency but led to some measurable exposure.

Antithrombotic quinoxazolines

Quinoxazolines having antithrombotic activity. Exemplary of those disclosed are: 4-{[6-(N-carboxymethyl-quinolin-8-yl-sulphonylamino)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzamidine, 4-{[6-(1-(N-cyclopentyl-carboxymethylcarbonylamino)-cyclo-propyl)-1-methyl-2-oxo-1,2-dihydroquinoxalin-3-yl]-methyl}-benzamidine, and 4-{[7-(N-carboxymethylaminocarbonyl-ethylamino)-4-methyl-quinolin-2-yl]-oxo}-benzamidine.