61487-25-0

Basic information

• Product Name: (2-Amino-3-chlorophenyl)methanol
• Synonyms: (2-Amino-3-chlorophenyl)methanol;2-AMino-3-chlorobenzyl Alcohol;2-Amino-3-chlorobenzenemethanol;(2-Amino-3-chlorophenyl)
• CAS NO: 61487-25-0
• Molecular Formula: C₇H₈ClNO
• Molecular Weight: 157.599
• Product Categories: Amines;Aromatics;Miscellaneous Reagents
• Mol File: 61487-25-0.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 296.283 °C at 760 mmHg
• Flash Point: 132.987 °C
• Appearance: /
• Density: 1.341 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.631
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Solubility: Dichloromethane, Ethyl Acetate
• CAS DataBase Reference: (2-Amino-3-chlorophenyl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-Amino-3-chlorophenyl)methanol(61487-25-0)
• EPA Substance Registry System: (2-Amino-3-chlorophenyl)methanol(61487-25-0)

Safety Data

• Hazardous Substances Data: 61487-25-0(Hazardous Substances Data)

Usage

Chemical Properties

Light Brown Solid

Uses

(2-Amino-3-chlorophenyl)methanol is a useful reactant in the synthesis of CGRP-receptor antagonists and PI3K inhibitors.

InChI:InChI=1/C7H8ClNO/c8-6-3-1-2-5(4-10)7(6)9/h1-3,10H,4,9H2

Upstream product

• 6388-47-2 2-amino-3-chlorobenzoic acid 
• 77820-58-7 methyl 3-chloroanthranilate 

Downstream Products

• 885609-96-1 N-(2-chloro-6-(hydroxymethyl)phenyl)pivalamide 
• 910297-65-3 3-chloro-2-(2-chloroacetamido)benzyl 2-chloroacetate 
• 98968-64-0 2-amino-3-chlorobenzyl acetate 
• 1242061-77-3 N-(6-chloro-2-formylphenyl)-4-methylbenzenesulfonamide 
• 397322-82-6 2-amino-3-chlorophenylformaldehyde 
• 1269261-75-7 2-(bromomethyl)-8-chloro-1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydroquinoline 
• 1269261-57-5 N-(2-(but-3-en-1-yl)-6-chlorophenyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

Chiral Phosphoric-Acid-Catalyzed Cascade Prins Cyclization

Asymmetric Prins cyclization of in situ generated quinone methides and o-aminobenzaldehyde has been developed with chiral phosphoric acid as an efficient catalyst. This unconventional method provides a facile access to diverse functionalized trans-fused pyrano-/furo-tetrahydroquinoline derivatives in excellent yield and with excellent diastereo- and enantioselectivities (up to 99% yield and 99% ee). Mechanistic studies suggested that the three adjacent tertiary stereocenters were constructed through the sequential formation of C-O, C-C, and C-N bonds.

Enantioselective synthesis of tunable chiral pyridine-aminophosphine ligands and their applications in asymmetric hydrogenation

A small library of tunable chiral pyridine-aminophosphine ligands were enantioselectively synthesized based on chiral 2-(pyridin-2-yl)-substituted 1,2,3,4-tetrahydroquinoline scaffolds, which were obtained in high yields and with excellent enantioselectivities via ruthenium-catalyzed asymmetric hydrogenation of 2-(pyridin-2-yl)quinolines. The protocol features a wide substrate scope and mild reaction conditions, enabling scalable synthesis. These chiral P,N ligands were successfully applied in the Ir-catalyzed asymmetric hydrogenation of benchmark olefins and challenging seven-membered cyclic imines including benzazepines and benzodiazepines. Excellent enantio- and diastereoselectivity (up to 99% ee and >20:1 dr), and/or unprecedented chemoselectivity were obtained in the asymmetric hydrogenation of 2,4-diaryl-3H-benzo[b]azepines and 2,4-diaryl-3H-benzo[b][1,4]diazepines.

HETEROCYCLIC COMPOUNDS AND THEIR USE AS INHIBITORS OF PI3K ACTIVITY

Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorde