6160-50-5Relevant articles and documents
Design, synthesis, and biological evaluation of C1-phosphonamidate analogues of 2-deoxy-d-ribose-1-phosphate
Quintiliani, Maurizio,Balzarini, Jan,McGuigan, Christopher
, p. 9111 - 9119 (2013)
A novel series of phenoxy C1-phosphonamidate derivatives of 2-deoxy-d-ribose have been synthesised as stable analogues of 2-deoxy-α-d-ribose-1-phosphate. A number of synthetic routes were explored for the preparation of these targets. The successful approach involved the synthesis of a protected C1-phosphonate ester 17 via Michaelis-Arbuzov reaction, which was then hydrolysed and coupled with different amino acid esters using aldrithiol. Subsequent hydrogenolysis afforded the targets 2a-g, which were isolated as a mixture of diastereoisomers. The compounds were assayed for inhibition of thymidine phosphorylase (TP) and uridine phosphorylase (UP) and for antiviral and cytostatic activity.
COMPOSITION COMPRISING PAEONIFLORIN OR ALBIFLORIN ANALOGUE, METHOD OF PREPARATION THEREOF
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, (2018/04/20)
A composition comprises a compound of formula (I) and at least one cosmetically acceptable carrier. It can be used for preventing or decreasing skin pigmentation and /or lightening skin tone.
Zeolite-Based Organic Synthesis (ZeoBOS) of Acortatarin A: First Total Synthesis Based on Native and Metal-Doped Zeolite-Catalyzed Steps
Wimmer, Eric,Borghèse, Sophie,Blanc, Aurélien,Bénéteau, Valérie,Pale, Patrick
, p. 1484 - 1489 (2017/02/10)
Similarly to polymer-supported assisted synthesis (PSAS), organic synthesis could be envisaged being performed by using zeolites, native or metal-doped, as heterogeneous catalysts. To illustrate this unprecedented Zeolite-Based Organic Synthesis (ZeoBOS),
