61600-71-3Relevant articles and documents
Synthesis and SAR of thiophene containing kinesin spindle protein (KSP) inhibitors
Pinkerton, Anthony B.,Lee, Tom T.,Hoffman, Timothy Z.,Wang, Yan,Kahraman, Mehmet,Cook, Travis G.,Severance, Daniel,Gahman, Timothy C.,Noble, Stewart A.,Shiau, Andrew K.,Davis, Robert L.
, p. 3562 - 3569 (2008/12/23)
We have identified and synthesized a series of thiophene containing inhibitors of kinesin spindle protein. SAR studies led to the synthesis of 33, which was co-crystallized with KSP and determined to bind to an allosteric pocket previously described for o
Derivatives of thiophene
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, (2008/06/13)
New dicyclic thiophene compounds having the structural formula STR1 wherein X is an ester or cyano group and Y is a substituted amino group. The compounds are useful as agricultural chemicals and particularly as ripeners for sugarcane.
