617688-33-2Relevant articles and documents
Novel antibiotics: C-2 symmetrical macrocycles inhibiting Holliday junction DNA binding by E. coli RuvC
Pan, Po-Shen,Curtis, Fiona A.,Carroll, Chris L.,Medina, Irene,Liotta, Lisa A.,Sharples, Gary J.,McAlpine, Shelli R.
, p. 4731 - 4739 (2007/10/03)
Holliday junctions (HJs) are formed as transient DNA intermediates during site-specific and homologous recombination. Both of these genetic exchange pathways are critical for normal DNA metabolism and repair. Trapping HJs leads to bacterial cell death by
Novel antibiotics: Second generation macrocyclic peptides designed to trap Holliday junctions
Liotta, Lisa A.,Medina, Irene,Robinson, Jennifer L.,Carroll, Chris L.,Pan, Po-Shen,Corral, Ricardo,Johnston, Jennifer V.C.,Cook, Kristina M.,Curtis, Fiona A.,Sharples, Gary J.,McAlpine, Shelli R.
, p. 8447 - 8450 (2007/10/03)
Described are the syntheses of 15 macrocyclic peptides designed to trap Holliday junctions (HJs) in bacteria during site-specific and homologous recombination. This leads to inhibiting bacterial growth. These second generation macrocycles were based on th