61771-18-4 Usage
Description
4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine, also known as Clemastine EP Impurity B, is a chemical compound derived from the synthesis of Clemastine Fumarate (C568500). It is a hexahydroazepine derivative with a 1-methyl group and an ethoxy side chain connected to a phenyl group, which is further connected to a 4-chlorophenyl group. 4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine has a complex structure and is characterized by its potential role as an impurity in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine is used as an impurity in the synthesis of Clemastine Fumarate (C568500) for its role as an H1 histamine receptor antagonist and antihistaminic. The presence of this impurity in the synthesis process can affect the quality, safety, and efficacy of the final pharmaceutical product. Therefore, its identification, control, and minimization are crucial for maintaining the desired properties of Clemastine Fumarate.
In the pharmaceutical industry, the primary application of 4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine is related to its presence as an impurity in the synthesis of Clemastine Fumarate. Clemastine Fumarate is a well-known antihistamine drug used to treat various allergic conditions, such as rhinitis, urticaria, and pruritus. As an impurity, 4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine can impact the overall effectiveness and safety of the drug. It is essential to monitor and control the levels of this impurity during the manufacturing process to ensure the quality and efficacy of the final product.
While the provided materials do not mention other specific applications of 4-[1-(4-Chlorophenyl)-1-phenylethoxy]-1-methylhexahydro-1H-azepine in different industries, it is worth noting that chemical compounds with similar structures may have potential uses in various fields, such as chemical research, material science, or even as intermediates in the synthesis of other pharmaceutical compounds. However, without further information, it is not possible to provide a detailed list of applications in other industries.
Check Digit Verification of cas no
The CAS Registry Mumber 61771-18-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,7,7 and 1 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 61771-18:
(7*6)+(6*1)+(5*7)+(4*7)+(3*1)+(2*1)+(1*8)=124
124 % 10 = 4
So 61771-18-4 is a valid CAS Registry Number.
61771-18-4Relevant articles and documents
Synthesis of (-)-(S, S)-clemastine by invertive N → C aryl migration in a lithiated carbamate
Fournier, Anne M.,Brown, Robert A.,Farnaby, William,Miyatake-Ondozabal, Hideki,Clayden, Jonathan
supporting information; experimental part, p. 2222 - 2225 (2010/08/04)
The first enantioselective synthesis of the antihistamine agent clemastine, as its (S,S)-stereoisomer, has been achieved by ether formation between a proline-derived chloroethylpyrrolidine and an enantiomerically enriched tertiary alcohol. The tertiary alcohol was formed from the carbamate derivative of α-methyl-p-chlorobenzyl alcohol by invertive aryl migration on lithiation. The (S,S)-stereochemistry of the product confirms the invertive nature of the rearrangement.
