618-30-4Relevant articles and documents
Synthesis and biological properties of novel glucocorticoid androstene C-17 furoate esters
Sandham, David A.,Barker, Lucy,Beattie, David,Beer, David,Bidlake, Louise,Bentley, David,Butler, Keith D.,Craig, Sarah,Farr, David,Ffoulkes-Jones, Claire,Fozard, John R.,Haberthuer, Sandra,Howes, Colin,Hynx, Deborah,Jeffers, Sarah,Keller, Thomas H.,Kirkham, Paul A.,Maas, Janet C.,Mazzoni, Lazzaro,Nicholls, Andrew,Pilgrim, Gaynor E.,Schaebulin, Elisabeth,Spooner, Gillian M.,Stringer, Rowan,Tranter, Pamela,Turner, Katharine L.,Tweed, Morris F.,Walker, Christoph,Watson, Simon J.,Cuenoud, Bernard M.
, p. 5213 - 5224 (2004)
A series of novel corticosteroid derivatives featuring C-17 furoate ester functionality have been synthesised. Profiling in vitro and in vivo has resulted in the identification of a compound with a longer duration of action and a lower oral side effect profile in rodents compared to budesonide.
NICOTINIC ACETYLCHOLINE RECEPTORSUB-TYPE SELECTIVE AMIDES OF DIAZABICYCLOALKANES
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Page/Page column 32, (2008/12/05)
Compounds, pharmaceutical compositions including the compounds, and methods of preparation and use thereof are disclosed. The compounds are amide compounds which can be prepared from certain heteoraryl carboxylic acids and certain diazabicycloalkanes. The
Phosphorylamides, their preparation and use
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, (2008/06/13)
A phosphorylamide derivative represented by the general formula (I): STR1 wherein R represents an amino group that may be substituted, or a salt thereof, possesses potent antibacterial activity against Helicobacter bacterium, especially Helicobacter pylori, and is useful for prevention or treatment of digestive diseases caused by Helicobacter bacterium, solely or in combination with an antacid or an acid secretion inhibitor.
