618461-78-2

Basic information

• Product Name: (R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE
• Synonyms: (R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE;(R)-(+)-(4-BROMOPHENYL)ETHYL ISOCYANATE;(R)-1-Bromo-4-(1-isocyanatoethyl)benzene
• CAS NO: 618461-78-2
• Molecular Formula: C₉H₈BrNO
• Molecular Weight: 226.07
• EINECS: -0
• Mol File: 618461-78-2.mol
• Article Data: 2

Chemical Properties

• Melting Point: 30-32°C
• Boiling Point: 145-147°C 7mm
• Flash Point: 145-147°C/7mm
• Appearance: /
• Density: 1.4±0.1 g/cm³
• Vapor Pressure: 0.00483mmHg at 25°C
• Refractive Index: 1.562
• Sensitive: Moisture Sensitive
• BRN: 7869672
• CAS DataBase Reference: (R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE(618461-78-2)
• EPA Substance Registry System: (R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE(618461-78-2)

Safety Data

• Statements: 20/22-36/37/38
• Safety Statements: 23-26-36/37/39
• RIDADR: 2206
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 618461-78-2(Hazardous Substances Data)

Usage

General Description

(R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE is a chemical compound with the molecular formula C9H8BrNO. It is a potentially hazardous chemical that is highly reactive and can easily polymerize. (R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE is commonly used in the synthesis of various organic compounds, such as pharmaceuticals, agrochemicals, and materials science. It has been found to have a wide range of applications in the field of chemistry, particularly in the development of new substances with unique properties. (R)-(+)-1-(4-BROMOPHENYL)ETHYL ISOCYANATE is also used as a reagent in organic synthesis and as an intermediate in the production of various other chemicals. Due to its reactive nature, it should be handled with caution and proper safety measures should be taken when working with it.

InChI:InChI=1/C9H8BrNO/c1-7(11-6-12)8-2-4-9(10)5-3-8/h2-5,7H,1H3/t7-/m1/s1

Upstream product

• 32315-10-9 bis(trichloromethyl) carbonate 
• 24358-62-1 (R)-1-(4-bromophenyl)ethylamine 
• 75-44-5 phosgene 

Downstream Products

• 1110641-96-7 (S)-6-allyl-3-((R)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one 
• 1110642-53-9 (R)-6-allyl-3-((R)-1-(4-bromophenyl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one 
• 1110641-99-0 (R)-3-((R)-1-(2',4'-difluoro-[1,1'-biphenyl]-4-yl)ethyl)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one 
• 1110642-51-7 (S)-3-((R)-1-(2',4'-difluoro-[1,1'-biphenyl]-4-yl)ethyl)-6-(4-fluorophenyl)-6-(2-hydroxyethyl)-1,3-oxazinan-2-one 

Relevant articles and documents

SYNTHESIS OF INHIBITORS OF 11BETA-HYDROXYSTEROID DEHYDROGENASE TYPE 1

Disclosed are syntheses of 11 beta-HSD1 inhibitors and corresponding intermediates that are promising for the treatment of a variety of disease states including diabetes, metabolic syndrome, obesity, glucose intolerance, insulin resistance, hyperglycemia, hypertension, hypertension-related cardiovascular disorders, hyperlipidemia, deleterious gluco-corticold effects on neuronal function (e.g. cognitive impairment, dementia, and/or depression), elevated intra-ocular pressure, various forms of bone disease (e.g., osteoporosis), tuberculosis, leprosy (Hansen's disease), psoriasis, and impaired wound healing (e.g., in patients that exhibit impaired glucose tolerance and/or type 2 diabetes).