61889-48-3 Usage
Description
3-(2-Chloroacetyl)pyridine hydrochloride is an organic compound characterized by the presence of a chloroacetyl group attached to a pyridine ring. This chemical entity is a key intermediate in the synthesis of various pharmaceuticals and agrochemicals due to its unique structural features and reactivity.
Uses
Used in Pharmaceutical Synthesis:
3-(2-Chloroacetyl)pyridine hydrochloride is used as a synthetic intermediate for the preparation of chiral amino(pyridinyl)ethanol. 3-(2-Chloroacetyl)pyridine hydrochloride is crucial in the development of enantiomerically pure pharmaceuticals, which are essential for ensuring the desired therapeutic effects and minimizing potential side effects associated with racemic mixtures.
Used in Enzymatic Kinetic Resolution:
3-(2-Chloroacetyl)pyridine hydrochloride is utilized in the lipase-mediated kinetic resolution process. This enzymatic approach allows for the selective transformation of one enantiomer over the other, leading to the production of chiral amino(pyridinyl)ethanol with high enantioselectivity and yield. This method is particularly valuable in the pharmaceutical industry, where the synthesis of enantiomerically pure compounds is of utmost importance for drug development and safety.
Check Digit Verification of cas no
The CAS Registry Mumber 61889-48-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,1,8,8 and 9 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 61889-48:
(7*6)+(6*1)+(5*8)+(4*8)+(3*9)+(2*4)+(1*8)=163
163 % 10 = 3
So 61889-48-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H6ClNO/c8-4-7(10)6-2-1-3-9-5-6/h1-3,5H,4H2
61889-48-3Relevant articles and documents
NOVEL SULFONAMIDE SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA-3 ADRENORECEPTOR AGONISTS
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Page/Page column 26-27, (2008/12/07)
This invention relates to novel sulfonamide substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
A scalable asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride via an oxazaborolidine catalyzed borane reduction
Duquette, Jason,Zhang, Mingbao,Zhu, Lei,Reeves, Raymond S.
, p. 285 - 288 (2013/09/06)
This report describes a scalable process for the asymmetric synthesis of (R)-2-amino-1-(3-pyridinyl)ethanol dihydrochloride. The stereochemistry of the product is set via a reduction of 3-chloroacetyl pyridine with 2 equiv of borane-dimethyl sulfide and a catalytic amount of an in situ generated oxazaborolidine. The enantiomeric excess (ee) of the reductive step depends on the addition rate of the substrate and the temperature. The authors hypothesize that the low ee observed during a fast addition of the substrate or at low temperatures is due to the slow regeneration of the active catalyst from the catalyst-product complex.
CARBOXYL SUBSTITUTED CHROMAN DERIVATIVES USEFUL AS BETA 3 ADRENORECEPTOR AGONISTS
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, (2011/11/14)
This invention is related to novel carboxyl substituted chroman derivatives which are useful in the treatment of beta-3 receptor mediated conditions.
