619-41-0

Basic information

• Product Name: 2-Bromo-4'-methylacetophenone
• Synonyms: P-TOLYL ETHYL KETONE;ETHYL-P-TOLYLKETON;LABOTEST-BB LT00053050;2-Bromo-p-methylacetophenone;Acetophenone, 2-bromo-4'-methyl-;alpha-Bromo-4-methylacetophenone;alpha-Bromo-p-methylacetophenone;omega-Bromo-p-methylacetophenone
• CAS NO: 619-41-0
• Molecular Formula: C₉H₉BrO
• Molecular Weight: 213.07
• EINECS: 226-267-5
• Product Categories: Aromatic Acetophenones & Derivatives (substituted);C9;Carbonyl Compounds;Ketones;Acetophenone series;Aromatics
• Mol File: 619-41-0.mol
• Article Data: 155

Chemical Properties

• Melting Point: 45-49 °C(lit.)
• Boiling Point: 238-239 °C(lit.)
• Flash Point: 229 °F
• Appearance: White to light yellow/Crystalline Powder or Needles
• Density: 0.993 g/mL at 25 °C(lit.)
• Refractive Index: n20/D 1.528(lit.)
• Storage Temp.: -20?C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), Ethyl Acetate
• Stability: Stable. Incompatible with strong oxidizing agents, strong bases.
• BRN: 607041
• CAS DataBase Reference: 2-Bromo-4'-methylacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Bromo-4'-methylacetophenone(619-41-0)
• EPA Substance Registry System: 2-Bromo-4'-methylacetophenone(619-41-0)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-27-37/39
• RIDADR: UN 2811
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 619-41-0(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powder

Uses

2-Bromo-4′-methylacetophenone was used in the general fluorous thiol quenching method. It was also used in the preparation of hydroxyquinolinone and N-derivatized carboxamides.

General Description

2-Bromo-4′-methylacetophenone is an α-bromoketone.

Upstream product

• 108773-83-7 3-Bromomethyl-4,4-dimethyl-3-p-tolyl-[1,2]dioxetane 
• 67-66-3 chloroform 
• 7726-95-6 bromine 
• 122-00-9 para-methylacetophenone 
• 64-19-7 acetic acid 
• 7664-93-9 sulfuric acid 
• 33491-05-3 1-(2-bromoethynyl)-4-methylbenzene 
• 622-97-9 1-ethenyl-4-methylbenzene 
• 536-50-5 CH₃C₆H₄CH(CH₃)OH 
• 51270-89-4 1-(1-bromoethenyl)-4-methylbenzene 
• 186581-53-3 diazomethane 
• 874-60-2 4-methyl-benzoyl chloride 
• 99-94-5 p-Toluic acid 
• 92520-13-3 N-(1-(4-methylphenyl)ethyl)acetamide 

Downstream Products

• 82746-47-2 p-methylphenacyl-α-picolinium bromide 
• 65964-61-6 7-methyl-2-(4-methylphenyl)imidazo[1,2-a]pyridine 
• 5330-68-7 2,6-dimethyl-4-(4-methyl-phenacylmercapto)-pyrylium; bromide 
• 109614-34-8 2-p-toluoyl-benzofuran-3-carboxylic acid ethyl ester 
• 122262-57-1 3-hydroxy-6-methyl-2-(4-methylphenyl)quinoline-4-carboxylic acid 
• 146537-25-9 1-(4-methylphenyl)-2-(4-methylphenylamino)ethanone 
• 153783-84-7 2-((2-oxo-2-(p-tolyl)ethyl)thio)acetic acid 
• 4872-78-0 2-hydrazino-4-(4'-tolyl)thiazole 
• 55577-25-8 2-(4-methylphenyl)-1H-indole 
• 857566-01-9 2-(N-ethyl-anilino)-1-p-tolyl-ethanone 
• 16163-66-9 2-(5-amino-2-imino-[1,3,4]thiadiazol-3-yl)-1-p-tolyl-ethanone 
• 206983-57-5 pifithrin‐α 
• 60477-34-1 2-(4-methylphenyl)-5,6,7,8-tetrahydrobenzo[d]-imidazo[2,1-b]thiazole 
• 63208-71-9 7-methyl-2-p-tolyl-5,6,7,8-tetrahydro-benzo[d]imidazo[2,1-b]thiazole 

Relevant articles and documents

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions

A practical synthesis of α-bromo/iodo/chloroketones from olefins under visible-light irradiation conditions has been developed. In the presence of PhI(OAc)2 as promoter and under ambient conditions, the reactions of styrenes and triiodomethane undergo the transformation smoothly to deliver the corresponding α-iodoketones without additional photocatalyst in good yields under sunlight irradiation. Meanwhile, the reactions of styrenes with tribromomethane and trichloromethane generate the desired α-bromoketones and α-chloroketones in high yields by using Ru(bpy)3Cl2 as a photocatalyst under blue LED (450–455 nm) irradiation.

Thiazole ring-containing amide compounds as well as preparation method and application thereof

The invention discloses thiazole ring-containing amide compounds as well as a preparation method and application thereof, and belongs to the field of chemical technologies and pesticides. According to the present invention, p-phenylenediamine is adopted as a raw material to synthesize a series of the thiazole ring-containing amide compounds, and the synthesized thiazole ring-containing amide compounds have good inhibition effects on Xanthomonas oryzae pv.Oryza (Xoo), Xanthomonas oryzae pv.Oryzcola (Xoc) and Xanthomonas axonophora pv.Citri (Xac) in agricultural diseases and insect pests, and can be used for preparing the anti-plant bacterium agent.

Facile Synthesis of α-Haloketones by Aerobic Oxidation of Olefins Using KX as Nonhazardous Halogen Source

An operationally simple and safe synthesis of α-haloketones using KBr and KCl as nonhazardous halogen sources is reported. It involves an iron-catalysed reaction of alkenes with KBr/KCl using O2 as terminal oxidant under the irradiation of visible-light. This strategy avoids the risks associated with handling halo-contained electrophiles (Cl2, Br2, NCS, NBS). The process is tolerant to several functional groups, and extended to a range of substituted styrenes in up to 89% yield. A radical reaction pathway is proposed based on control experiments and spectroscopy studies.