619-57-8Relevant articles and documents
Sustainable synthesis of drug intermediates via simultaneous utilization of carbon monoxide and ammonia over Pd@La-MOF
Bhattacharya, Sumantra,Bordoloi, Ankur,Das, Subhasis,Gazi, Jahiruddin,Islam, Sk Manirul,Prasad, V. V. D. N.,Sengupta, Manideepa
, (2022/03/14)
Mitigation of carbon monoxide and ammonia to valuable primary aromatic amides is an imperative approach to control the environmentally harmful emissions thereby infusing towards sustainability. Designing of nanostructured catalyst for direct access to the synthetically valuable primary aromatic and heteroaromatic amides via carbonylative amination of aryl halides is always demanding since nano materials can bridge the gap between homogeneous and heterogeneous catalysis thus preserving the desirable attributes of both the systems towards sustainable catalysis. Herein, microwave assisted fabrication of highly uniform Pd NPs (3,4 nm) over La-MOFs has been performed and utilized efficiently for ligand free carbonylative amination of aryl iodides with carbon monoxide and ammonia. Moderate to high yields of benzamide derivatives, salicylamide, a drug having analgesic and antipyretic properties were achieved. The unsaturated metal sites in the MOF via synergistic mode of σ and π bonding binds with CO, which significantly enhances the catalytic activity of MOF-composite unlike other supported Pd NPs. DFT confirms the growth of pristine Pd13 cluster within the framework, as active metal center for the carbonylative amination.
Production method of anisonitrile
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Paragraph 0039-0041; 0045-0047; 0051-0053, (2021/03/30)
The invention belongs to the technical field of chemical engineering, and particularly relates to a production method of anisonitrile, which comprises: 1) carrying out an amidation reaction on p-hydroxybenzoic acid and carbamate under the action of a catalyst to generate p-hydroxybenzamide, 2) synthesizing p-methoxybenzamide from p-hydroxybenzamide in dimethyl carbonate under the action of the catalyst, and 3) dehydrating the p-methoxybenzamide in dimethyl carbonate in the presence of a dehydrating agent at 80-90 DEG C for 3-6 hours to obtain the anisonitrile. The purity of the anisonitrile product obtained by the production method is as high as 99.4%-99.8%, the yield of the anisonitrile product is as high as 98.0%-99.2%, the total yield of the reaction is as high as 95.7%-98.1% based on p-hydroxybenzoic acid, the yield is high, highly toxic substances are not used in the production process, no wastewater is generated, the used solvent is safe, environment-friendly and easy to recover,the raw materials are low in price, and large-scale production can be achieved.
Iron-catalyzed arene C-H hydroxylation
Cheng, Lu,Wang, Huihui,Cai, Hengrui,Zhang, Jie,Gong, Xu,Han, Wei
, p. 77 - 81 (2021/10/05)
The sustainable, undirected, and selective catalytic hydroxylation of arenes remains an ongoing research challenge because of the relative inertness of aryl carbon-hydrogen bonds, the higher reactivity of the phenolic products leading to over-oxidized by-products, and the frequently insufficient regioselectivity. We report that iron coordinated by a bioinspired L-cystine-derived ligand can catalyze undirected arene carbon-hydrogen hydroxylation with hydrogen peroxide as the terminal oxidant. The reaction is distinguished by its broad substrate scope, excellent selectivity, and good yields, and it showcases compatibility with oxidation-sensitive functional groups, such as alcohols, polyphenols, aldehydes, and even a boronic acid. This method is well suited for the synthesis of polyphenols through multiple carbon-hydrogen hydroxylations, as well as the late-stage functionalization of natural products and drug molecules.
