619-60-3

Basic information

• Product Name: 4-(dimethylamino)phenol
• Synonyms: 4-(dimethylamino)phenol;4-N,N-DIMETHYLAMINOPHENOL;N,N-Dimethyl-4-aminophenol;N,N-Dimethyl-p-hydroxyaniline;p-(Dimethylamino)phenol;p-Hydroxy-N,N-dimethylaniline;Phenol,4-(diMethylaMino)-;Phenol, p-(dimethylamino)-
• CAS NO: 619-60-3
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.17904
• EINECS: 210-604-8
• Mol File: 619-60-3.mol
• Article Data: 48

Chemical Properties

• Melting Point: 138-141℃
• Boiling Point: 260℃
• Flash Point: 136℃
• Appearance: /
• Density: 1.089
• Vapor Pressure: 0.00789mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 10.11±0.13(Predicted)
• CAS DataBase Reference: 4-(dimethylamino)phenol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(dimethylamino)phenol(619-60-3)
• EPA Substance Registry System: 4-(dimethylamino)phenol(619-60-3)

Safety Data

• Hazardous Substances Data: 619-60-3(Hazardous Substances Data)

Usage

General Description

4-(Dimethylamino)phenol is a chemical compound with the formula C8H11NO. It is a white crystalline solid with a molecular weight of 137.18 g/mol. This chemical is commonly used as a pH indicator in chemistry experiments, with a color change from colorless to pink in the pH range of 6.8 to 8.2. It is also utilized as a reagent in organic synthesis and as a raw material in the production of pharmaceuticals and dyes. Additionally, 4-(Dimethylamino)phenol has potential applications in the fields of photography and hair dyes. However, it is important to handle this chemical with caution, as it can be harmful if ingested, inhaled, or absorbed through the skin, and it may cause irritation or sensitization upon contact. Therefore, appropriate safety precautions should be taken when working with this compound.

InChI:InChI=1/C8H11NO.C2H2O4/c1-9(2)7-3-5-8(10)6-4-7;3-1(4)2(5)6/h3-6,10H,1-2H3;(H,3,4)(H,5,6)

Upstream product

• 109-99-9 tetrahydrofuran 
• 60-29-7 diethyl ether 
• 591-51-5 phenyllithium 
• 701-56-4 4-methoxy-N,N-dimethylanilne 
• 121-69-7 N,N-dimethyl-aniline 
• 150-75-4 N-methyl-p-aminophenol 
• 74-88-4 methyl iodide 
• 51-61-6 dopamine 
• 54737-34-7 4-(N,N-dimethylamino)phenoxyl radical 
• 1953-54-4 indol-5-ol 
• 56305-04-5 trolox 
• 331-39-5 caffeic acid 
• 138-65-8 Norepinephrine 
• 1199-18-4 6-Hydroxydopamin 

Downstream Products

• 10604-88-3 methyl-carbamic acid-(4-dimethylamino-phenyl ester) 
• 111293-74-4 tetra-N-methyl-4,4'-pentanediyldioxy-di-aniline 
• 102081-56-1 N-[3-(4-dimethylamino-phenoxy)-propyl]-phthalimide 
• 14200-18-1 4-Dimethylamino-3-isopropyl-phenol 
• 109728-10-1 sulfurous acid bis-(4-dimethylamino-phenyl ester) 
• 132886-53-4 chlorothiophosphoric acid O,O'-bis-(4-dimethylamino-phenyl ester) 
• 5944-82-1 phosphoric acid tris-(4-dimethylamino-phenyl ester) 
• 41445-40-3 tris(4-(N,N-dimethylamino)phenyl) phosphite 
• 109444-29-3 4-(2-dimethylamino-ethoxy)-N,N-dimethyl-aniline 
• 104177-42-6 3-(4-dimethylamino-phenoxy)-propane-1,2-diol 
• 123056-31-5 hexa-N-methyl-4,4'-butanediyldioxy-di-anilinium; diiodide 
• 91801-05-7 [4-(4-Chloro-butoxy)-phenyl]-dimethyl-amine 
• 97227-10-6 (S)-3,3-Dimethyl-7-oxo-6-(2-phenoxy-acetylamino)-4-thia-1-aza-bicyclo[3.2.0]heptane-2-carboxylic acid 4-dimethylamino-phenyl ester 
• 3958-86-9 2-(N,N-dimethylamino)-1,4-benzoquinone 

Relevant articles and documents

Energetics of an n → π* interaction that impacts protein structure

(Figure Presented) The trans/cis ratio of the amide bond in N-formylproline phenylesters correlates with electron withdrawal by a para substituent. The slope of the Hammett plot (ρ = 0.26) is indicative of a substantial effect. This effect arises from a favorable n → π* interaction between the amide oxygen and ester carbonyl. In a polypeptide chain, an analogous interaction can stabilize the conformation of trans peptide bonds, α-helices, and polyproline type-II helices.

Synthesis method of substituted phenol

The invention provides a synthesis method of substituted phenol. The target product substituted phenol is prepared by taking substituted benzene as an initial raw material, and the whole synthetic process is high in selectivity, high in yield, convenient to operate and high in atom economy.

Heterogeneous Palladium–Chitosan–CNT Core–Shell Nanohybrid Composite for Ipso-hydroxylation of Arylboronic Acids

Abstract: A novel palladium-nanohybrid (Pd–Chitosan–CNT) catalytic composite has been developed using CNT–chitosan nanocomposite and palladium nitrate. The prepared catalytic platform displays excellent catalytic reactivity for the ipso-hydroxylation of various arylboronic acids with a mild oxidant aqueous H2O2 at room temperature, affording the corresponding phenols in excellent yields. Significantly, the easy recovery and reusability by simple manipulation demonstrate the green credentials of this catalytic platform. Graphical Abstract: [Figure not available: see fulltext.]