61946-92-7

Basic information

• Product Name: 3-methyl-N-hydroxy-benzenecarboximidoyl chloride
• Synonyms: 3-methyl-N-hydroxy-benzenecarboximidoyl chloride
• CAS NO: 61946-92-7
• Molecular Weight: 169.611
• Mol File: 61946-92-7.mol
• Article Data: 18

Chemical Properties

• CAS DataBase Reference: 3-methyl-N-hydroxy-benzenecarboximidoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 3-methyl-N-hydroxy-benzenecarboximidoyl chloride(61946-92-7)
• EPA Substance Registry System: 3-methyl-N-hydroxy-benzenecarboximidoyl chloride(61946-92-7)

Safety Data

• Hazardous Substances Data: 61946-92-7(Hazardous Substances Data)

Upstream product

• 52707-50-3 3-methylbenzaldehyde oxime 
• 587-03-1 3-methylbenzyl alcohol 
• 104-87-0 4-methyl-benzaldehyde 
• 620-23-5 m-tolyl aldehyde 

Downstream Products

• 82075-99-8 3-(3-m-Tolyl-[1,2,4]oxadiazol-5-yl)-1H-indole 
• 82076-03-7 3-(3-m-Tolyl-[1,2,4]oxadiazol-5-ylmethyl)-1H-indole 
• 86387-52-2 N-Hydroxy-3-methyl-thiobenzimidic acid 2-diethylamino-ethyl ester; hydrochloride 
• 1346772-11-9 (Z)-N'-hydroxy-3-methyl-N-propylbenzimidamide 
• 1346643-50-2 4-propyl-3-m-tolyl-1,2,4-oxadiazol-5(4H)-one 
• 1399860-62-8 3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10)-trien-17β-ol 
• 1399860-74-2 3-methoxy-17α-[3'-(3-methyl)phenylisoxazol-5'-yl]estra-1,3,5(10),16-tetraene 
• 1422283-20-2 C₁₃H₁₅NO₂ 
• 1422283-29-1 C₁₃H₁₃NO₃ 
• 1613642-65-1 C₂₈H₁₈N₄O₂ 
• 1613643-09-6 C₂₈H₂₆N₄O₂ 
• 1613643-10-9 C₃₀H₃₀N₈O₂ 
• 1613642-64-0 C₂₆H₂₀N₂O₂ 
• 124463-96-3 m-methylbenzonitrile 

Relevant articles and documents

Ru-Catalyzed [3 + 2] Cycloaddition of Nitrile Oxides and Electron-Rich Alkynes with Reversed Regioselectivity

Polarity reversal ("umpolung") of a functional group can override its inherent reactivity and lead to distinct bond-forming modes. Herein we describe a rarely studied cycloaddition between nitrile oxides and electron-rich alkynes with reversed regioselect

Electrochemical synthesis of 1,2,4-oxadiazoles from amidoximes through dehydrogenative cyclization

A convenient and efficient method for the generation of the iminoxy radical through anodic oxidation was developed for the synthesis of 3,5-disubstituted 1,2,4-oxadiazoles fromN-benzyl amidoximes. The transformation proceeds through 1.5-Hydrogen Atom Transfer (1,5-HAT) and intramolecular cyclization. The process features simple operation, mild conditions, broad substrate scope and high functional group compatibility, and provides a facile and practical way for the preparation of 1,2,4-oxadiazoles.

Design, synthesis, and in vitro evaluation of novel triazole analogues featuring isoxazole moieties as antifungal agents

In order to develop novel antifungal agents, based on our previous work, a series of (2R,3R)-3-((3-substitutied-isoxazol-5-yl)methoxy)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl) butan-2-ol (a1-a26) were designed and synthesized. All of the compounds exhibited good in vitro antifungal activities against eight human pathogenic fungi. Among them, compound a6 showed excellent inhibitory activity against Candida albicans and Candida parasilosis with MIC80 values of 0.0313 μg/mL. In addition, compounds a6, a9, a12, a13 and a14 exhibited moderate inhibitory activities against fluconazole-resistant isolates with MIC80 values ranging from 8 μg/mL to 16 μg/mL. Furthermore, compounds a6, a12 and a23 exhibited low inhibition profiles for CYP3A4. Clear SARs were analyzed, and the molecular docking experiment was carried out to further investigate the relationship between a6 and the target enzyme CYP51.