6201-65-6

Basic information

• Product Name: 2-Chlororesorcinol
• Synonyms: 2-Chlorobenzene-1,3-diol;2-CHLORORESORCINOL;2,6-DIHYDROXYCHLOROBENZENE;2-Chloro-1,3-dihydroxybenzene;2-Chlorresorcine;2-CHLORORESORCINOL / 1-CHLORO-2,6-DIHYDROXYBENZENE;2-CHLORO-1,3-BENZENEDIOL/2-CHLORO-RESORCINOL;2-Chloro-1,3-dihydroxybenzene, 2-Chlorobenzene-1,3-diol
• CAS NO: 6201-65-6
• Molecular Formula: C₆H₅ClO₂
• Molecular Weight: 144.56
• EINECS: 228-256-0
• Product Categories: Intermediates of Dyes and Pigments
• Mol File: 6201-65-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 94-99 °C
• Boiling Point: 244.1 °C at 760 mmHg
• Flash Point: 101.4 °C
• Appearance: White solid
• Density: 1.471 g/cm³
• Vapor Pressure: 0.0198mmHg at 25°C
• Refractive Index: 1.629
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 7.98±0.10(Predicted)
• CAS DataBase Reference: 2-Chlororesorcinol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Chlororesorcinol(6201-65-6)
• EPA Substance Registry System: 2-Chlororesorcinol(6201-65-6)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41-52/53
• Safety Statements: 26-36/37/39-61
• WGK Germany: 3
• Hazardous Substances Data: 6201-65-6(Hazardous Substances Data)

Usage

Chemical Properties

2-Chlororesorcinol is a white solid, density: 1.471 g/cm3, boiling point: 244.1oC at 760 mmHg, melting point: 94-99oC.

Uses

2-Chlororesorcinol is a phenolic derivative and can be used as a pharmaceutical intermediate for pharmaceutical synthesis and research.

InChI:InChI=1/C6H5ClO2/c7-6-4(8)2-1-3-5(6)9/h1-3,8-9H

Upstream product

• 36942-09-3 N,N-dichlorourea 
• 108-46-3 recorcinol 
• 7647-01-0 hydrogenchloride 
• 7732-18-5 water 
• 17530-74-4 2,2-Dichloro-1,3-cyclohexanedione 

Downstream Products

• 2513-50-0 2-(3-chloro-2,4-dihydroxybenzoyl)benzoic acid 
• 2320-96-9 4',5'-Dichlorofluorescein 
• 7051-15-2 2-chlororesorcinol dimethyl ether 
• 16606-61-4 2,4-dichlororesorcinol 
• 116920-31-1 1,3-dihydroxy-2-chloro-4,6-dinitrobenzene 

Relevant articles and documents

Synthetic molecules for labeling histidine-rich proteins

The invention provides Zn-chelating compounds that are molecularly engineered to bind to a specific target sequence in a protein of interest. The Zn2+0 ion is far less toxic and promiscuous than nickel and therefore provides an attractive alternative to Ni-based labeling systems. Invention Zn-chelating compounds also do not require oxidizable thiols and therefore can be used in non-reducing environments such as the surface of living cells. In addition, the target sequence is genetically encodable and requires incorporation of only a few amino acids, unlike fusions to fluorescent proteins such as GFP.

Synthesis of diaminoresorcinal from resorcinol

The invention relates to a novel process for preparing 4,6-diaminoresorcinol, a precursor to polybenzoxazole, from resorcinol according to the following scheme. STR1 Resorcinol (I) is reacted with a di-tert-alkylating reagent to form a 4,6,-di-tert-alkylresorcinol (II), which is then halogenated to form a 2-halo-4,6-di-tert-alkylresorcinol (III). The 2-halo-4,6-di-tert-alkylresorcinol is nitrated in one of two ways to form a 2-halo-4,6-dinitroresorcinol (IV), which is then hydrogenated to from the 4,6-diaminoresorcinol. The invention also relates to a novel chemical composition-2-halo-4,6-di-tert-alkylresorcinol (III )--and a process for preparing same.

Preparation of halogenated phenols

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