62041-01-4

Basic information

• Product Name: 3-Amino-4-imino-rifamycin S
• Synonyms: 3-AMino-4-deoxy-4-iMino RifaMycin S;RifaMycin,3-aMino-1,4-dideoxy-1,4-dihydro-4-iMino-1-oxo-
• CAS NO: 62041-01-4
• Molecular Formula: C₃₇H₄₇N₃O₁₁
• Molecular Weight: 709.788
• Product Categories: Intermediate of Rifabutin;Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 62041-01-4.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 917.4±65.0 °C(Predicted)
• Appearance: /
• Density: 1.37±0.1 g/cm3(Predicted)
• Vapor Pressure: 0-0Pa at 20-25℃
• PKA: 4?+-.0.70(Predicted)
• CAS DataBase Reference: 3-Amino-4-imino-rifamycin S(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-imino-rifamycin S(62041-01-4)
• EPA Substance Registry System: 3-Amino-4-imino-rifamycin S(62041-01-4)

Safety Data

• Hazardous Substances Data: 62041-01-4(Hazardous Substances Data)

Usage

Uses

Rifabutin Intermediate

Upstream product

• 57375-25-4 3-bromo rifamycin S 
• 62623-68-1 rifamycin S 

Relevant articles and documents

Preparation method for rifamycin S derivative

The invention relates to a preparation method for a rifamycin S derivative. According to the preparation method, 3-amino-4-imine rifamycin S as shown in a formula II which is described in the specification and a 4-piperidone derivative as shown in a formula III which is described in the specification are added according to a certain feeding mode and subjected to a condensation reaction in the presence of an organic solvent, ammonium acetate and zinc dust so as to produce the rifamycin S derivative as shown in a formula I which is described in the specification. The feeding mode is that the 3-amino-4-imine rifamycin S is added into a reaction system in a final step, so 3-amino-4-imine rifamycin S is prevented from reduction and hydrolysis. The preparation method increases the utilization rate of materials and is shortened in reaction time, so high-efficiency high-yield preparation of the rifamycin S derivative is realized, and the yield and content of the rifamycin S derivative reach 80% or above and 95% or above, respectively; and the preparation method overcomes the problems of long reaction time, low yield, many impurities and high cost, and is simple to operate, highly efficient, environment friendly and beneficial for large-scale production.