620957-95-1

Basic information

• Product Name: Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate
• Synonyms: Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate;4-Chloro-6-methyl-2-quinazolinecarboxylic acid ethyl ester
• CAS NO: 620957-95-1
• Molecular Formula: C₁₂H₁₁ClN₂O₂
• Molecular Weight: 250.68094
• Mol File: 620957-95-1.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 405.3 °C at 760 mmHg
• Flash Point: 198.9 °C
• Appearance: /
• Density: 1.301 g/cm³
• Vapor Pressure: 8.89E-07mmHg at 25°C
• Refractive Index: 1.605
• PKA: -0.60±0.30(Predicted)
• CAS DataBase Reference: Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate(620957-95-1)
• EPA Substance Registry System: Ethyl 4-chloro-6-methyl-2-quinazolinecarboxylate(620957-95-1)

Safety Data

• Hazardous Substances Data: 620957-95-1(Hazardous Substances Data)

Usage

InChI:InChI=1/C12H11ClN2O2/c1-3-17-12(16)11-14-9-5-4-7(2)6-8(9)10(13)15-11/h4-6H,3H2,1-2H3

Upstream product

• 2941-78-8 2-Amino-5-methylbenzoic acid 
• 869294-64-4 ethyl 6-methyl-4-oxo-3,4-dihydroquinazoline-2-carboxylate 
• 58677-05-7 ethyl 2-amino-5-methylbenzoate 

Downstream Products

• 620957-92-8 4-{[(1S,2R)-2-({(tert-butoxycarbonyl)amino[(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-N-(4-methoxyphenyl)-6-methylquinazoline-2-carboxamide 
• 620957-97-3 4-{[(1S,2R)-2-({(tert-butoxycarbonyl)amino[(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-N-isobutyl-6-methylquinazoline-2-carboxamide 
• 620957-88-2 4-{[(1S,2R)-2-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-6-methylquinazoline-2-carboxylic acid ethyl ester 
• 620957-82-6 4-{[(1S,2R)-2-({[(tert-butoxycarbonyl)amino][(tert-butoxycarbonyl)imino]methyl}amino)cyclohexyl]amino}-6-methylquinazoline-2-carboxylic acid 
• 620957-84-8 ethyl 4-({(1S,2R)-2-[(tert-butoxycarbonyl)amino]cyclohexyl}amino)-6-methylquinazolin-2-carboxylate 

Relevant articles and documents

Synthesis and evaluation of quinazolines as inhibitors of the bacterial cell division protein FtsZ

The bacterial cell division protein FtsZ is one of many potential targets for the development of novel antibiotics. Recently, zantrin Z3 was shown to be a cross-species inhibitor of FtsZ; however, its specific interactions with the protein are still unknown. Herein we report the synthesis of analogues that contain a more tractable core structure and an analogue with single-digit micromolar inhibition of FtsZs GTPase activity, which represents the most potent inhibitor of Escherichia coli FtsZ reported to date. In addition, the zantrin Z3 core has been converted to two potential photo-cross-linking reagents for proteomic studies that could shed light on the molecular interactions between FtsZ and molecules related to zantrin Z3.