621-22-7

Basic information

• Product Name: 1,3,5-trihydroxyamino-benzene
• Synonyms: 1,3,5-cyclohexanetrione trioxime;1,3,5-trihydroxyamino-benzene;phloroglucinoltrioxime;1,3,5-Cyclohexanetrione trisoxime;Cyclohexane-1,3,5-trione trisoxime;Phloroglucin trioxime;cyclohexane-1,3,5-trione oxime;N-[3,5-bis(hydroxyimino)cyclohexylidene]hydroxylamine
• CAS NO: 621-22-7
• Molecular Formula: C₆H₉N₃O₃
• Molecular Weight: 171.15
• Mol File: 621-22-7.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 491 °C at 760 mmHg
• Flash Point: 326.5 °C
• Appearance: /
• Density: 1.6 g/cm³
• CAS DataBase Reference: 1,3,5-trihydroxyamino-benzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-trihydroxyamino-benzene(621-22-7)
• EPA Substance Registry System: 1,3,5-trihydroxyamino-benzene(621-22-7)

Safety Data

• Hazardous Substances Data: 621-22-7(Hazardous Substances Data)

Usage

General Description

1,3,5-trihydroxyamino-benzene, also known as 1,3,5-triaminophenol or Aminophenol, is a chemical compound with the molecular formula C6H9NO3. It is a crystalline solid that is soluble in water and ethanol. 1,3,5-trihydroxyamino-benzene is commonly used in the production of hair dyes, pharmaceuticals, and as a developer in photography. It has antioxidant properties and is used in cosmetic products for its anti-aging and skin rejuvenating effects. However, it is important to handle this chemical with care as it can be toxic when ingested in large amounts and may cause skin and eye irritation.

Upstream product

• 108-73-6 3,5-dihydroxyphenol 
• 30770-49-1 1,3,5-cyclohexanetrione 

Downstream Products

• 108-72-5 1,3,5-triaminobenzene 
• 787619-76-5 1,3,5-trinitrosobenzene 
• 99-35-4 1,3,5-trinitrobenzene 
• 78870-37-8 1,3,5-tris(N,O-diacetylhydroxyamino)benzene 
• 26243-62-9 N,N,N-triacetyl-1,3,5-triaminobenzene 
• 78870-35-6 1,3-diacetamido-5-(N,O-diacetylhydroxyamino)benzene 
• 78870-36-7 1,3-bis(N,O-diacetylhydroxyamino)-5-acetamidobenzene 
• 78870-34-5 1,3-diacetamido-5-(N-acetylhydroxyamino)benzene 
• 26150-46-9 cis,cis-1,3,5-triaminocyclohexane 
• 74421-58-2 cis,trans-1,3,5-triaminocyclohexane 

Relevant articles and documents

A facile two-step synthesis of 1,3,5-trinitrobenzene

Synthesis of 1,3,5-trinitrobenzene was achieved by converting phloroglucinol into its trioximes by reaction with aqueous hydroxylamine followed by oxidation of the trioxime product with 90% nitric acid.

Synthetic method for 1,3,5-triaminobenzene

The invention provides a synthetic method for 1,3,5-triaminobenzene. The method comprises the following steps: with phloroglucinol as shown in a structural formula IV which is described in the specification as a reaction raw material, subjecting the phloroglucinol and hydroxylamine hydrochloride to an oxime-forming reaction under an alkaline condition, and carrying out filtering and drying treatment so as to obtain 1,3,5-cyclohexanetrione oxime as shown in a structural formula III which is described in the specification; and subjecting the 1,3,5-cyclohexanetrione oxime to a hydrogenation reaction, and carrying out purification treatment so as to obtain 1,3,5-triaminobenzene as shown in a structural formula II which is described in the specification. According to the invention, a starting raw material used in the method is the phloroglucinol which is cheap and easily-available; an intermediate namely the 1,3,5-cyclohexanetrione oxime is non-explosive and facilitates separation and purification; and compared with a conventional method, the method provided by the invention has low cost and safe process. The method for preparation of the 1,3,5-triaminobenzene provided by the inventionadopts a hydrazine hydrate solution as a reducing reagent, does not need using strong acid and strong alkali, or catalytic hydrogenation under a normal pressure, and has the advantages of simple process, safety, low cost and environment friendliness.