621-31-8

Basic information

• Product Name: 3-ETHYLAMINOPHENOL
• Synonyms: 3-(ethylamino)-pheno;3-(ethylamino)phenol;m-(ethylamino)-pheno;m-(ethylamino)phenol;3-Hydroxyphenylethylamine
• CAS NO: 621-31-8
• Molecular Formula: C₈H₁₁NO
• Molecular Weight: 137.17904
• EINECS: 210-678-1
• Mol File: 621-31-8.mol
• Article Data: 21

Chemical Properties

• Melting Point: 62°C
• Boiling Point: 252.03°C (rough estimate)
• Flash Point: 147.2 °C
• Appearance: Very viscous deep orange liquid
• Density: 1.0630 (rough estimate)
• Vapor Pressure: 0.00202mmHg at 25°C
• Refractive Index: 1.5560 (estimate)
• Storage Temp.: 2-8°C
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 10.36±0.10(Predicted)
• CAS DataBase Reference: 3-ETHYLAMINOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-ETHYLAMINOPHENOL(621-31-8)
• EPA Substance Registry System: 3-ETHYLAMINOPHENOL(621-31-8)

Safety Data

• Statements: 34
• Safety Statements: 26-36/37/39
• RIDADR: 1759
• Hazardous Substances Data: 621-31-8(Hazardous Substances Data)

Usage

Uses

3-(Ethylamino)phenol can be used for hair dye compositions.

General Description

Very viscous deep orange liquid.

Air & Water Reactions

3-ETHYLAMINOPHENOL may be sensitive to prolonged exposure to air. . Slightly soluble in water.

Reactivity Profile

An amine and phenol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Phenols do not behave as organic alcohols, as one might guess from the presence of a hydroxyl (-OH) group in their structure. Instead, they react as weak organic acids. Phenols and cresols are much weaker as acids than common carboxylic acids (phenol has Ka = 1.3 x 10^[-10]). These materials are incompatible with strong reducing substances such as hydrides, nitrides, alkali metals, and sulfides. Flammable gas (H2) is often generated, and the heat of the reaction may ignite the gas. Heat is also generated by the acid-base reaction between phenols and bases. Such heating may initiate polymerization of the organic compound. Phenols are sulfonated very readily (for example, by concentrated sulfuric acid at room temperature). The reactions generate heat. Phenols are also nitrated very rapidly, even by dilute nitric acid.

Fire Hazard

Flash point data for 3-ETHYLAMINOPHENOL are not available, however, 3-ETHYLAMINOPHENOL is probably combustible.

InChI:InChI=1/C8H11NO/c1-2-9-7-4-3-5-8(10)6-7/h3-6,9-10H,2H2,1H3

Upstream product

• 50617-74-8 N-ethyl-1,3-benzenediamine 
• 103-69-5 N-ethyl-N-phenylamine 
• 618-13-3 3-ethylaminobenzenesulfonic acid 
• 108-46-3 recorcinol 
• 621-42-1 meta-hydroxyacetanilide 
• 591-27-5 m-Hydroxyaniline 
• 75-03-6 ethyl iodide 
• 75-05-8 acetonitrile 
• 74-96-4 ethyl bromide 

Downstream Products

• 100010-02-4 3-(ethyl-hexyl-amino)-phenol 
• 59443-99-1 3-(ethyl-propyl-amino)-phenol 
• 126444-32-4 10-Ethyl-8-hydroxy-3-phenyl-10H-pyrimido[4,5-b]quinoline-2,4-dione 
• 645352-55-2 [ethyl-(3-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester 
• 645352-57-4 [ethyl-(4-formyl-3-hydroxy-phenyl)-amino]-acetic acid tert-butyl ester 
• 28821-18-3 4-methyl-7-ethylamino-2H-benzopyran-2-one 
• 915777-42-3 3-(ethyl(3-hydroxy-4-nitrosophenyl)amino)propane-1-sulfonic acid hydrochloride 
• 79691-86-4 10-Ethyl-8-hydroxy-3-methyl-2,4(3H,10H)-pyrimido<4,5-b>chinolindion 
• 79691-87-5 6-(3-Hydroxy-N-ethyl-anilino)-3-methyl-2,4(1H,3H)-pyrimidindion 

Relevant articles and documents

OXAZINE-BASED WATER-SOLUBLE FLUOROPHORE COMPOUNDS FOR IN VIVO NERVE IMAGING

This invention provides novel oxazine-based, water soluble fluorophore compounds useful in in vivo nerve imaging, as well as compositions comprising them and methods for their use.

Structural modifications of nile red carbon monoxide fluorescent probe: Sensing mechanism and applications

Carbon monoxide (CO) is a cell-signaling molecule (gasotransmitter) produced endogenously by oxidative catabolism of heme, and the understanding of its spatial and temporal sensing at the cellular level is still an open challenge. Synthesis, optical properties, and study of the sensing mechanism of Nile red Pd-based CO chemosensors, structurally modified by core and bridge substituents, in methanol and aqueous solutions are reported in this work. The sensing fluorescence "off-on" response of palladacycle-based sensors possessing low-background fluorescence arises from their reaction with CO to release the corresponding highly fluorescent Nile red derivatives in the final step. Our mechanistic study showed that electron-withdrawing and electron-donating core substituents affect the rate-determining step of the reaction. More importantly, the substituents were found to have a substantial effect on the Nile red sensor fluorescence quantum yields, hereby defining the sensing detection limit. The highest overall fluorescence and sensing rate enhancements were found for a 2-hydroxy palladacycle derivative, which was used in subsequent biological studies on mouse hepatoma cells as it easily crosses the cell membrane and qualitatively traces the localization of CO within the intracellular compartment with the linear quantitative response to increasing CO concentrations.

NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION

Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.