621-71-6Relevant articles and documents
MANUFACTURING METHOD OF MIDDLE CHAIN ALIPHATIC ACID TRIGLYCERIDE, AND MANUFACTURING DEVICE OF MIDDLE CHAIN ALIPHATIC ACID TRIGLYCERIDE
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Paragraph 0078-0143; 0153-0161, (2019/08/12)
PROBLEM TO BE SOLVED: To provide a method capable of manufacturing a middle chain aliphatic acid triglyceride having good color tone and excellent stability, and a manufacturing device using the method. SOLUTION: There is disclosed a manufacturing method of middle chain aliphatic acid triglyceride and a manufacturing device of middle chain aliphatic acid triglyceride. The manufacturing method includes (a) a process for supplying a reaction system containing middle chain aliphatic acid and glycerin to an esterification reaction to obtain a reaction product containing the middle chain aliphatic acid triglyceride, (b) a process for removing unreacted middle chain aliphatic acid from the reaction product to obtain a reacted de-aliphatic acid product, and (c) a process for distilling the reacted de-aliphatic acid product using a thin film distillation machine to obtain a distilled product. SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2019,JPOandINPIT
Enzymatic synthesis of 1,3-dicaproyglycerol by esterification of glycerol with capric acid in an organic solvent system
Sanchez, Daniel Alberto,Tonetto, Gabriela Marta,Ferreira, Maria Lujan
, p. 7 - 18 (2014/01/06)
In this work, the esterification of glycerol with capric acid catalyzed by an immobilized form of a 1,3-positionally selective lipase (Rhizomucor miehei) showed to be effective for the synthesis of 1,3-dicaprin in n-heptane as the reaction medium. The effects of the reaction parameters were studied using an experimental factorial design of three factors and three levels with two central points. The selected experimental variables were amount of glycerol adsorbed on silica gel (G), biocatalyst load (E) and reaction temperature (T), and the response variables were total conversion of capric acid, acylglycerol fractions, selectivity and yield of dicaprin, and acyl migration reaction. The range of each parameter was selected as follows: G = 50-250 mg, E = 20-40 mg and T = 40-60 C. At optimum conditions 73% capric acid conversion was achieved, with 76% dicaprin selectivity, and selectivity to the specific 1,3-dicaprin of 70% of total products. An adequate selection of the reaction conditions is necessary not only to maximize the conversion of capric acid, but also to minimize the acyl migration reaction and the generation of undesired products. Evidence of kinetically controlled enzymatic acyl migration from sn-3/sn-1 to sn-2 is presented.
TREATMENT OF NEURODEGENERATIVE CONDITIONS
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Page/Page column 26-27, (2008/06/13)
A method is provided for treating a patient in need of therapy for a neurodegenerative disease comprising administering to that patient a therapeutically effective dose of a lipid glyceride comprising a glycerol moiety and a fatty acid moiety, the fatty acid moiety being selected from the group consisting of γ-linolenic acid, dihomo-γ-linolenic acid and arachidonic acid characterised in that the selected fatty acid moiety is attached to the glycerol moiety at its sn-2 position. Preferably the method is that wherein the lipid is administered for a duration and at a dose sufficient to maintain or elevate TGF-β1 levels in the patient to therapeutic levels.