6214-64-8Relevant articles and documents
RECYCLIZATION OF 5-CARBETHOXY-4-METHYL-2-MERCAPTO(AMINO, HYDROXY) PYRIMIDINES TO GIVE 5-ACETYL-2-MERCAPTO(AMINO, HYDROXY)-4-HYDROXYPYRIMIDINES
Vartanyan, R. S.,Kazaryan, Zh. V.,Vartanyan, S. A.
, p. 1212 - 1213 (1982)
Conditions for the selective preparation of 5-carbethoxy-4-methyl-2-substituted pyrimidines or 5-acetyl-4-hydroxy-2-substituted pyrimidines by condensation of ethoxymethyleneacetoacetic ester with 1,3-binucleophiles are proposed.It is shown that under the influence of sodium ethoxide 5-carbethoxy-4-methyl-2-substituted pyrimidines undergo rearrangement to 5-acetyl-4-hydroxy-2-substituted pyrimidines.
Synthesis of 4-aminoquinoline - Pyrimidine hybrids as potent antimalarials and their mode of action studies
Singh, Kamaljit,Kaur, Hardeep,Chibale, Kelly,Balzarini, Jan
, p. 314 - 323 (2013/10/01)
One of the most viable options to tackle the growing resistance to the antimalarial drugs such as artemisinin is to resort to synthetic drugs. The multi-target strategy involving the use of hybrid drugs has shown promise. In line with this, new hybrids of
A novel convenient synthesis of 5-acyl-1,2-dihydropyrimidin-2-ones via 4-trichloromethyl-1,2,3,4-tetrahydropyrimidin-2-ones
Fesenko, Anastasia A.,Solovyev, Pavel A.,Shutalev, Anatoly D.
experimental part, p. 940 - 946 (2010/03/24)
A novel four-step methodology for the synthesis of 5-acyl-1,2-dihydropyrimidin-2-ones has been developed. The reaction of readily available N-[(1-acetoxy-2,2,2-trichloro)ethyl]ureas with Na-enolates of 1,3-diketones or β-oxoesters followed by heterocycliz