62147-27-7

Basic information

• Product Name: H-HYP-OBZL HCL
• Synonyms: TRANS-4-HYDROXY-L-PROLINE ALPHA-BENZYL ESTER HYDROCHLORIDE;L-4-TRANS-HYDROXYPROLINE BENZYL ESTER HYDROCHLORIDE;L-4-HYDROXY-PROLINE BENZYL ESTER HYDROCHLORIDE;L-HYDROXYPROLINE BENZYL ESTER HYDROCHLORIDE;HYDROXYPROLINE-OBZL HCL;H-HYP-OBZL HCL;L-4-HYDROXY-PROLINE BENZYL ESTER HYDROCH;L-4-hydroxy-prolinebenzylesterHCl
• CAS NO: 62147-27-7
• Molecular Formula: C₁₂H₁₅NO₃*ClH
• Molecular Weight: 257.71
• Product Categories: Peptide Synthesis;Proline Derivatives;Unnatural Amino Acid Derivatives
• Mol File: 62147-27-7.mol
• Article Data: 1

Chemical Properties

• Melting Point: 162-165 °C
• Boiling Point: 399.3°C at 760 mmHg
• Flash Point: 195.3°C
• Appearance: /
• Vapor Pressure: 4.31E-07mmHg at 25°C
• Storage Temp.: -15°C
• BRN: 3728745
• CAS DataBase Reference: H-HYP-OBZL HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-HYP-OBZL HCL(62147-27-7)
• EPA Substance Registry System: H-HYP-OBZL HCL(62147-27-7)

Safety Data

• WGK Germany: 3
• F: 3-10
• Hazardous Substances Data: 62147-27-7(Hazardous Substances Data)

Usage

Uses

L-4-Hydroxy-proline benzyl ester, HCl

InChI:InChI=1/C12H15NO3.ClH/c14-10-6-11(13-7-10)12(15)16-8-9-4-2-1-3-5-9;/h1-5,10-11,13-14H,6-8H2;1H/t10-,11+;/m1./s1

Upstream product

• 89813-47-8 N-(tert-butoxycarbonyl)-(2S,4R)-4-hydroxyproline benzyl ester 

Downstream Products

• 4252-82-8 (2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinecarboxylic acid 
• 141345-77-9 Boc-Gln-R-EtA-Hyp-OBzl 
• 141345-77-9 Boc-Gln-S-EtA-Hyp-OBzl 
• 141345-72-4 Boc-Leu-MeA-MeA-Hyp-OBzl 
• 1418120-52-1 (2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide 
• 1360616-29-0 (2S,4R)-4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)-N-(4-(oxazol-5-yl)benzyl)pyrrolidine-2-carboxamide 
• 1448189-55-6 (2S,4R)-benzyl 4-hydroxy-1-(2-(3-methylisoxazol-5-yl)acetyl)pyrrolidine-2-carboxylate 
• 141345-89-3 CF₃COOH*H-Gln-R-EtA-Hyp-MeA-Phol 

Relevant articles and documents

(4-HYDROXYPYRROLIDIN-2-YL)-HYDROXAMATE COMPOUNDS AND METHODS OF USE THEREOF

The present disclosure relates to bifunctional compounds, which can be used as modulators of targeted ubiquitination. In particular, the present disclosure is directed to compounds which contain on one end a VHL ligand moiety, which binds to the VHL E3 ubiquitin ligase, and on the other end a moiety that binds a target protein such that degradation of the target protein/polypeptide is effectuated. Also disclosed are VHL ligands.