62206-13-7

Basic information

• Product Name: 1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE
• Synonyms: 1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE;1-(5-CHLORO-2-NITROPHENYL)-6,7-DIMETHOXY-3,4-DIHYDROISOQUINOLINE
• CAS NO: 62206-13-7
• Molecular Formula: C₁₇H₁₅ClN₂O₄
• Molecular Weight: 346.77
• Product Categories: Quinoline&Isoquinoline
• Mol File: 62206-13-7.mol
• Article Data: 3

Chemical Properties

• Melting Point: 169 °C
• Boiling Point: 494.3 °C at 760 mmHg
• Flash Point: 252.7 °C
• Appearance: /
• Density: 1.37 g/cm³
• Vapor Pressure: 1.99E-09mmHg at 25°C
• Refractive Index: 1.625
• PKA: 4.40±0.20(Predicted)
• CAS DataBase Reference: 1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE(62206-13-7)
• EPA Substance Registry System: 1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE(62206-13-7)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 62206-13-7(Hazardous Substances Data)

Usage

General Description

1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE is a chemical compound with potential pharmacological properties. It is a dihydroisoquinoline derivative with a chloro-nitrophenyl group and two methoxy substituents on the isoquinoline ring. 1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE may have potential applications in drug discovery and development, particularly in the area of medicinal chemistry and pharmacology. It is important to note that this compound should be handled and used with care, as it may have specific safety considerations and potential hazards. Further research and analysis may be necessary to fully understand the properties and potential uses of 1-(5-CHLORO-2-NITROPHENYL)-3,4-DIHYDRO-6,7-DIMETHOXYISOQUINOLINE.

InChI:InChI=1/C17H15ClN2O4/c1-23-15-7-10-5-6-19-17(12(10)9-16(15)24-2)13-8-11(18)3-4-14(13)20(21)22/h3-4,7-9H,5-6H2,1-2H3

Upstream product

• 41994-44-9 5-chloro-2-nitrobenzoyl chloride 
• 2516-95-2 5-chloro-2-nitrobenzoic acid 
• 301174-19-6 5-chloro-N-[2-(3,4-dimethoxyphenyl)ethyl]-2-nitrobenzamide 

Downstream Products

• 62206-12-6 4-chloro-2-(6,7-dimethoxy-3,4-dihydroisoquinolin-1-yl)aniline 
• 62206-16-0 6,7-dimethoxy-1-(5-chloro-2-aminophenyl)-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

Synthesis and?antitumor activity of?cis-dichloroplatinum(II) complexes of?1-(2-aminophenyl)-1,2,3,4-tetrahydroisoquinolines

Fifteen cis-dichloroplatinum complexes (5a-5o) were synthesized by treatment of 1-(2-aminophenyl)-1,2,3,4-THIQs (4a-4o) with K2PtCl4. The antitumor activity of these compounds was examined against four different human tumor cell lines. Their structure-activity relationships for antitumor activity are reported. All of these compounds exhibited activity against MCF-7 cell line and showed good activity against WiDr cell line except 5c and 5f. On the other hand, compounds 5j and 5o are more active than the other compounds against Hepa59T/VGH cell line. The electron-donating group at the 6-position of isoquinoline ring seems to decrease the antitumor activity and the chloro substituent at the C-4 position of the aniline ring shown the highest potency. The "trans influence" dominates the control of the stability of [1-(2-aminophenyl)-1,2,3,4-THIQ]dichloroplatinums(II).

Synthesis of indazole-N-oxides via the 1,7-electrocyclization of azomethine ylides

The first examples of the 1,7-electrocyclization of azomethine ylides onto a nitro group, to give benz-1,2,6-oxadiazepine intermediates are reported. Subsequent ring contraction results in the formation of indazole-N-oxides. Graphical Abstract