622372-75-2

Basic information

• Product Name: 1-(azidomethyl)-2,4-difluorobenzene
• Synonyms: 1-(azidomethyl)-2,4-difluorobenzene
• CAS NO: 622372-75-2
• Molecular Weight: 169.134
• Mol File: 622372-75-2.mol
• Article Data: 15

Chemical Properties

• CAS DataBase Reference: 1-(azidomethyl)-2,4-difluorobenzene(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(azidomethyl)-2,4-difluorobenzene(622372-75-2)
• EPA Substance Registry System: 1-(azidomethyl)-2,4-difluorobenzene(622372-75-2)

Safety Data

• Hazardous Substances Data: 622372-75-2(Hazardous Substances Data)

Upstream product

• 23915-07-3 1-(bromomethyl)-2,4-difluorobenzene 
• 1550-35-2 2,4-difluorobenzaldehyde 
• 698-80-6 4-(chloromethyl)-1,2-difluorobenzene 
• 452-07-3 2,4-difluorobenzyl chloride 

Downstream Products

• 1253801-36-3 4-amino-N-((1-(2,4-difluorobenzyl)-1H-1,2,3-triazol-4-yl)methyl)benzenesulfonamide 
• 1550-35-2 2,4-difluorobenzaldehyde 

Relevant articles and documents

Synthesis, inhibition properties against xanthine oxidase and molecular docking studies of dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives

This study focused on synthesis various dimethyl N-benzyl-1H-1,2,3-triazole-4,5-dicarboxylate and (N-benzyl-1H-1,2,3-triazole-4,5-diyl)dimethanol derivatives under the conditions of green chemistry without the use of solvent and catalysts. Their inhibition properties were also investigated on xanthine oxidase (XO) activity. All dimethanol and dicarboxylate derivatives exhibited significant inhibition activities with IC50 values ranging from 0.71 to 2.25 μM. Especially, (1-(3-bromobenzyl)-1H-1,2,3-triazole-4,5-diyl)dimethanol (5c) and dimethyl 1-(4-chlorobenzyl)-1H-1,2,3-triazole-4,5-dicarboxylate (6 g) compounds were found to be the most promising derivatives on the XO enzyme inhibition with IC50 values 0.71 and 0.73 μM, respectively. Moreover, the double docking procedure was to evaluate compound modes of inhibition and their interactions with the protein (XO) at atomic level. Surprisingly, the docking results showed a good correlation with IC50 [correlation coefficient (R2 = 0.7455)]. Also, the docking results exhibited that the 5c, 6f and 6 g have lowest docking scores ?4.790, ?4.755, and ?4.730, respectively. These data were in agreement with the IC50 values. These results give promising beginning stages to assist in the improvement of novel and powerful inhibitor against XO.

Regioselective synthesis of 4-fluoro-1,5-disubstituted-1,2,3-triazoles from synthetic surrogates of α-fluoroalkynes

α-Fluoroalkynes are elusive molecules due to their instability and inaccessibility. Here, we show that α-fluoronitroalkenes can serve as synthetic surrogates of α-fluoroalkynes in [3+2] cycloaddition reactions with organic azides facilitated by a catalytic amount of trifluoroacetic acid (TFA). This work provides the first regioselective method to access 4-fluoro-1,5-disubstituted-1,2,3-triazoles.

Synthesis of 1,2,3-triazole derivatives of 4,4'-dihydroxybenzophenone and evaluation of their elastase inhibitory activity

The present investigation describes the synthesis of a series of novel triazole derivatives from 4,4'-dihydroxybenzophenone along with their elastase inhibitory activity. The 1,2,3-triazoles were obtained via the copper(I)-catalyzed azide-alkyne cycloaddi