62260-99-5 Usage
Description
DICHLOROMETHYLDIISOPROPOXYBORANE is an organoborane compound that serves as a versatile reagent in organic synthesis. It is characterized by its ability to form carbon-carbon and carbon-heteroatom bonds, making it a valuable tool in the synthesis of various organic compounds.
Uses
Used in Organic Synthesis:
DICHLOROMETHYLDIISOPROPOXYBORANE is used as a reagent for the formation of carbon-carbon and carbon-heteroatom bonds. Its unique properties allow for the efficient synthesis of complex organic molecules, making it a valuable asset in the field of organic chemistry.
Used in Medicinal Chemistry:
In the pharmaceutical industry, DICHLOROMETHYLDIISOPROPOXYBORANE is used as a key intermediate in the solid phase synthesis of aminoboronic acids. These aminoboronic acids have been identified as potent inhibitors of the hepatitis C virus NS3 proteinase, a crucial enzyme in the viral replication process. By targeting this enzyme, these inhibitors can help to combat the spread of the hepatitis C virus and potentially lead to the development of new antiviral therapies.
Overall, DICHLOROMETHYLDIISOPROPOXYBORANE is a versatile and valuable reagent in both organic synthesis and medicinal chemistry, with applications ranging from the formation of complex organic molecules to the development of novel antiviral agents.
Check Digit Verification of cas no
The CAS Registry Mumber 62260-99-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,2,2,6 and 0 respectively; the second part has 2 digits, 9 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 62260-99:
(7*6)+(6*2)+(5*2)+(4*6)+(3*0)+(2*9)+(1*9)=115
115 % 10 = 5
So 62260-99-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H15BCl2O2/c1-5(2)11-8(7(9)10)12-6(3)4/h5-7H,1-4H3
62260-99-5Relevant articles and documents
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Rathke,M.W. et al.
, p. 145 - 149 (1976)
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A practical synthesis of (dichloromethyl)- and (1,1-dichloroethyl)boronic esters
Malteson, Donald S.,Hurst, Gerald D.
, p. 1465 - 1467 (2008/10/08)
Addition of lithium diisopropylamide or diethylamide to a mixture of triisopropyl borate and dichloromethane in THF at temperatures between -78 and 0°C leads to formation of (dichloromethyl)lithium and its capture by the borate ester. Anhydrous HCl converts the resulting borate salt to diisopropyl (dichloromethyl)boronate. Similarly, dimethyl (1,1-dichloroethyl)boronate is readily prepared from 1,1-dichloroethane and trimethyl borate. Sodium iodide converted butanediol (dichloromethyl)boronate to the (diiodomethyl)boronate.
