623-61-0

Basic information

• Product Name: ISOPROPYL GLYCOLATE
• Synonyms: Propan-2-yl 2-hydroxyacetate;2-hydroxyacetic acid isopropyl ester;propan-2-yl 2-hydroxyethanoate;2-hydroxy-3-Methylbutanoate;isopropyl glycolat;Isopropyl 2-hydroxyacetate;ISOPROPYL GLYCOLATE;isopropyl hydroxyacetate
• CAS NO: 623-61-0
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• EINECS: 210-804-5
• Mol File: 623-61-0.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 159.3 °C at 760 mmHg
• Flash Point: 54.6 °C
• Appearance: /
• Density: 1.05 g/cm³
• Vapor Pressure: 0.889mmHg at 25°C
• Refractive Index: 1.42
• Storage Temp.: 2-8°C
• PKA: 13.21±0.10(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: ISOPROPYL GLYCOLATE(CAS DataBase Reference)
• NIST Chemistry Reference: ISOPROPYL GLYCOLATE(623-61-0)
• EPA Substance Registry System: ISOPROPYL GLYCOLATE(623-61-0)

Safety Data

• Hazardous Substances Data: 623-61-0(Hazardous Substances Data)

Usage

Uses

Isopropyl glycolate is used as pharmaceutical intermediate.

InChI:InChI=1/C5H10O3/c1-4(2)8-5(7)3-6/h4,6H,3H2,1-2H3

Upstream product

• 79-14-1 glycolic Acid 
• 67-63-0 isopropyl alcohol 
• 105-48-6 isopropyl chloroacetate 
• 590-29-4 potassium formate 
• 553-90-2 Dimethyl oxalate 
• 57-48-7 D-Fructose 
• 57-50-1 Sucrose 
• 50-99-7 D-glucose 
• 615-81-6 diisopropyl oxalate 
• 187737-37-7 propene 

Downstream Products

• 23684-11-9 Isopropoxycarbonylmethyl methacrylate 
• 1583259-17-9 isopropyl 2-((tert-butyldiphenylsilyl)oxy)acetate 
• 1583259-33-9 (2R,3R,4R)-isopropyl 5-(benzyloxy)-3-hydroxy-2-((tert-butyldiphenylsilyl)oxy)-4-(2,2,6,6-tetramethylpiperidin-1-yloxy)pentanoate 
• 1583259-32-8 (2R,3R,4R)-isopropyl 5-(benzyloxy)-3-hydroxy-2-((tert-butyldimethylsilyl)oxy)-4-(2,2,6,6-tetramethylpiperidin-1-yloxy)pentanoate 
• 1583259-18-0 (Z)-5-isopropoxy-2,2,3,3,9,9-hexamethyl-8,8-diphenyl-4,7-dioxa-3,8-disiladec-5-ene 
• 1027602-75-0 (4,5-Dimethoxy-2-nitro-phenoxy)-methoxymethoxy-acetic acid isopropyl ester 
• 1026806-90-5 Methoxymethoxy-(5-methoxy-2-nitro-phenoxy)-acetic acid isopropyl ester 
• 1026342-24-4 Methoxymethoxy-(2-nitro-phenoxy)-acetic acid isopropyl ester 

Relevant articles and documents

Preparation method of chlorophenoxyacetic ester

The invention provides a preparation method of chlorophenoxyacetic ester, wherein the preparation method comprises the following steps: A) carrying out reaction of glycolic acid and alcohol in tolueneto obtain glycolic ester; B) carrying out reaction of glycolic ester and metal alkoxide to obtain a metal salt of glycolic ester; and C) carrying out reaction of the metal salt of glycolic ester andchlorobenzene to obtain the chlorophenoxyacetic ester. The chlorophenoxyacetic ester is synthesized by condensation of chlorobenzene with the metal salt of glycolic ester, the use of chlorophenol withunpleasant odor is effectively avoided, the production of highly toxic dioxins is eliminated, and the product quality and the operating environment of the production site are greatly improved. Motherliquor containing effective ingredients cannot be produced, so the loss of effective ingredients is effectively avoided and the yield of the product is improved.

A general and enantioselective approach to pentoses: A rapid synthesis of PSI-6130, the nucleoside core of sofosbuvir

An efficient route towards biologically relevant pentose derivatives is described. The de novo synthetic strategy features an enantioselective α-oxidation reaction enabled by a chiral amine in conjunction with copper(II) catalysis. A subsequent Mukaiyama aldol coupling allows for the incorporation of a wide array of modular two-carbon fragments. Lactone intermediates accessed via this route provide a useful platform for elaboration, as demonstrated by the preparation of a variety of C-nucleosides and fluorinated pentoses. Finally, this work has facilitated expedient syntheses of pharmaceutically active compounds currently in clinical use.

NOVEL METHOD FOR THE CONVERSION OF CELLULOSE AND RELATED CARBOHYDRATE MATERIALS TO LOW-MOLECULAR-WEIGHT COMPOUNDS

Methods of converting cellulose or related biorenewable carbohydrate materials into high-value chemical compounds. The methods provide a means of converting low-cost materials such as cellulose and biomass into high yields of compounds such as ethylene glycol, propylene glycol, glycerin, methanol, hydroxyacetone, glycolaldehyde and dihydroxyacetone.