623158-27-0

Basic information

• Product Name: N-acetoxy-N-(1-methyl-5H-pyrido[4,3-b]indol-3-yl)acetamide
• Synonyms: N-acetoxy-N-(1-methyl-5H-pyrido[4,3-b]indol-3-yl)acetamide
• CAS NO: 623158-27-0
• Molecular Weight: 297.313
• Mol File: 623158-27-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-acetoxy-N-(1-methyl-5H-pyrido[4,3-b]indol-3-yl)acetamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-acetoxy-N-(1-methyl-5H-pyrido[4,3-b]indol-3-yl)acetamide(623158-27-0)
• EPA Substance Registry System: N-acetoxy-N-(1-methyl-5H-pyrido[4,3-b]indol-3-yl)acetamide(623158-27-0)

Safety Data

• Hazardous Substances Data: 623158-27-0(Hazardous Substances Data)

Upstream product

• 72254-58-1 Tryptophan p 2 acetate 

Relevant articles and documents

Synthesis and characterization of the aqueous solution chemistry of the food-derived carcinogen model N-acetoxy-N-(1-methyl-5H-pyrido[4,5-b]indol-3-yl)acetamide and its N-pivaloyloxy analogue

We report the synthesis of N-acetoxy-N-(1-methyl-5H-pyrido[4,5-b]indol-3-yl)acetamide, 7, its N-pivaloyloxy analogue, 9, and improved synthesis of indole-2-acetonitrile, 3 (70% in five steps from indole-2-carboxylic acid), the carcinogenic amine Trp-P-2, 4 (40% from 3), and the nitro compound, 5 (40% from 4 by oxidation with H2O2 using Mo(CO)6 catalyst). In aqueous solution at neutral pH, 7 primarily undergoes C-O bond cleavage to yield the hydroxamic acid, 8, but under the same conditions the sterically hindered 9 decomposes predominately by N-O bond cleavage with a pH independent rate constant that is 7.5-fold smaller than that for 7. In the pH range 0.5-7.0 three different processes for the decomposition of 9 were detected by kinetics. Only the process that dominates at neutral pH generates a nitrenium species that can be trapped by N3-.