624730-34-3

Basic information

• Product Name: 4-methylphenyl triisopropylsilyl sulfide
• Synonyms: 4-methylphenyl triisopropylsilyl sulfide
• CAS NO: 624730-34-3
• Molecular Weight: 280.55
• Mol File: 624730-34-3.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 4-methylphenyl triisopropylsilyl sulfide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methylphenyl triisopropylsilyl sulfide(624730-34-3)
• EPA Substance Registry System: 4-methylphenyl triisopropylsilyl sulfide(624730-34-3)

Safety Data

• Hazardous Substances Data: 624730-34-3(Hazardous Substances Data)

Upstream product

• 624-31-7 4-tolyl iodide 
• 29540-83-8 p-tolyl triflate 
• 156275-96-6 triisopropylsilanethiol 
• 106-38-7 para-bromotoluene 
• 106-43-4 para-chlorotoluene 

Downstream Products

• 649-15-0 N,N-diethyl-4-methylbenzenesulfonamide 
• 70-55-3 toluene-4-sulfonamide 

Relevant articles and documents

One-pot synthesis of unsymmetrical diaryl thioethers by palladium-catalyzed coupling of two aryl bromides and a thiol surrogate

Extraordinarily simple, convenient, and efficient: A general and operationally simple one-pot synthesis of unsymmetrical diaryl sulfides by coupling two different bromoarenes and triisopropylsilanethiol (TIPS-SH) is reported. This protocol overcomes the narrow availability of arene thiols and their instability to oxidation. These reactions catalyzed by palladium complexes generated from the alkylbisphosphine CyPF-tBu occur in good to excellent yields with wide scope and high tolerance of functional groups.

A general and efficient method for the synthesis of silyl-protected arenethiols from aryl halides or triflates

An improved palladium-catalyzed synthesis of silyl-protected arenethiols has been developed. This method is particularly useful because of its experimental simplicity, high generality and high level of functional group toleration. The first synthesis of enantiomerically pure [2.2]paracyclophane-4- thiol was realized employing this method.