624733-88-6

Basic information

• Product Name: MK-0812
• Synonyms: MK-0812;D-erythro-Pentitol, 1,5-anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-;1,5-Anhydro-2,3-dideoxy-3-[[(1R,3S)-3-[[7,8-dihydro-3-(trifluoromethyl)-1,6-naphthyridin-6(5H)-yl]carbonyl]-3-(1-methylethyl)cyclopentyl]amino]-4-O-methyl-D-erythro-pentitol;MK0812,MK-0812;MK0812(BASE)
• CAS NO: 624733-88-6
• Molecular Formula: C₂₄H₃₄F₃N₃O₃
• Molecular Weight: 469.545
• Mol File: 624733-88-6.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 562 °C at 760 mmHg
• Flash Point: 293.7 °C
• Appearance: /
• Density: 1.24
• Solubility: Soluble in DMSO
• PKA: 8.51±0.40(Predicted)
• CAS DataBase Reference: MK-0812(CAS DataBase Reference)
• NIST Chemistry Reference: MK-0812(624733-88-6)
• EPA Substance Registry System: MK-0812(624733-88-6)

Safety Data

• Hazardous Substances Data: 624733-88-6(Hazardous Substances Data)

Usage

Uses

MK-0812 is a potent C-C chemokine receptor type 2 (CCR2) antagonist.

Upstream product

• 625097-29-2 (3S,4S)-N-((1S,4S)-4-isopropyl-4-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-yl)-3-methoxytetrahydro-2H-pyran-4-amine 
• 851916-43-3 ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)-[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine benzenesulfonate 
• 624734-34-5 (1S,4S)-4-isopropyl-4-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopent-2-en-1-amine 
• 624734-17-4 3-methoxydihydro-2H-pyran-4(3H)-one 

Downstream Products

• 851916-43-3 ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)-[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine benzenesulfonate 
• 851916-42-2 ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)-[(3S,4S)-3-methoxytetrahydro-2H-pyran-4-yl]amine succinate 

Relevant articles and documents

CCR-2 ANTAGONIST SALT

The present invention provides an efficient synthesis for the preparation of ((1R,3S)-3-isopropyl-3-{[3-(trifluoromethyl)-7,8-dihydro-1,6-naphthyridin-6(5H)-yl]carbonyl}cyclopentyl)[(3S,4S)-3-m ethoxytetrahydro-2H-pyran-4-yl]amine and its succinate salt.

TETRAHYDROPYRANYL CYCLOPENTYL TETRAHYDROPYRIDOPYRIDINE MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY

The present invention is directed to compounds of the formula (I): (wherein R3 et R8 are defined herein) which are useful as modulators of chemokine receptor activity. In particular, these compounds are useful as modulators of the chemokine receptor CCR-2.